A case of urticaria pigmentosa
Keywords:
Mastocytosis, Darier's sign, Giemsa stain, mast cells, urticaria pigmentosaAbstract
Urticaria pigmentosa is the most common variant of cutaneous mastocytosis. A three and a half-month-old female child presented with generalized eruption of multiple brownish macular and papular lesions on the trunk, limbs, face and neck of two months duration. On stroking the individual lesion, there was formation of wheal and erythema (Darier's sign positive). Histopathological examination of lesional skin and staining with Giemsa stain and hematoxylin eosin showed infiltration of numerous spindle shaped mast cells in perivascular and periappendageal location in the upper dermis. These findings were suggestive of mastocytosis. There was no systemic involvement. We present a typical case of urticaria pigmentosa."References
Harvard CWH, Scott RB. Urticaria with visceral and skeletal lesions. Q J Med. 1959;28:459-61.
Caplan RM. The natural history of urticaria pigmentosa. Analysis and follow up of 112 cases. Arch Dermatol. 1963;87:146-48.
Morelli JG. Diseases of the dermis. In: Kliegman RM, Stanton BF, Geme JWS et al., editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: Saunders; 2011. P. 2273-81.
Habif TP, editor. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 4th ed. St. Louis: Mosby; 2004.
Tharp DM. Mastocytosis. In: Goldsmith AL, Katz SI, Gilhrest AB et al., editors. Fitzpatrick's Dermatology in General Medicine. 8th edn. New York: McGraw- Hill; 2012. P.1809-18 .
Garriga MM, Friedman MM, Metcalfe DD. A survey of the number and distribution of mast cells in the skin of patients with mast cell disorders. J Allergy Clin Immunol. 1988;82:425-32.
Grattan CEH, Black AK. Urticaria and Mastocytosis. In: Burns T, Breathnach S, Griffiths C, editors. Rook's Textbook of Dermatology, 8th ed. West Sussex: Wiley- Blackwell; 2010. P.22.1-22.35
