Progressive macular hypomelanosis: a report of three cases
Keywords:
Progressive macular hypomelanosis, hypopigmented macules, narrow-band ultraviolet BAbstract
Progressive macular hypomelanosis (PMH) is an acquired disorder of skin pigmentation, of uncertain etiology, characterized by asymptomatic hypopigmented macules, predominantly located on the trunk. There are several treatment options available, although topical clindamycin and benzoyl peroxide have been used traditionally. Good results have recently been achieved using narrow-band ultraviolet B (NB-UVB) phototherapy. Herein three cases one male and two females, belonging to ethnic Kashmiri population with progressive macular hypomelanosis are reported in view of the clinical rarity of this condition.ÂReferences
Guillet G, Helenon R, Gauthier Y et al. Progressive macular hypomelanosis of the trunk: primary acquired hypopigmentation. J Cutan Pathol. 1988;15:286-9.
Guillet G, Halenon R, Guillet MH et al. Progressive and confluent hypomelanosis of the melanodermic metis. Ann Dermatol Venereol. 1992;119:19-24.
Kumarasinghe SPW, Tan SH, Thng S et al. Progressive macular hypomelanosis in Singapore: a clinico-pathological study. Int J Dermatol. 2006;45:737-42.
Westerhof W, Relyveld GN, Kingswijk MM et al. Propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis. Arch Dermatol. 2004;140:210-4.
Relyveld G, Dingemans KP, Menke HE et al. Ultrastructural findings in progressive macular hypomelanosis indicate decreased melanin production. J Eur Acad Dermatol Venereol. 2008;22:568-74.
Chung YL, Goo B, Chung WS et al. A case of progressive macular hypomelanosis treated with narrow-band UVB. J Eur Acad Dermatol Venereol. 2007;21:1007-9.
Relyveld GN, Kingswijk MM, Reitsma JB et al. Benzoyl peroxide/clindamycin/UVA is more effective than fluticasone/UVA in progressive macular hypomelanosis: A randomized study. J Am Acad Dermatol. 2006;55:836-43.