Generalized morphea and hypothyroidism: Case report of a rare association
Keywords:
Generalized morphea, hypothyroidism, sclerodermaAbstract
Morphea is a localized form of scleroderma in which there is predominant skin involvement, with occasional involvement of subjacent muscles and usually spares the internal organs. Thyroid dysfunction has been reported in systemic sclerosis but it has been rarely reported in morphea. There are few case reports of plaque-type morphea associated with autoimmune thyroiditis but generalized morphea with hypothyroidism has been rarely reported. We report a 55-year-old female with generalized morphea involving trunk and proximal limbs who revealed hypothyroidism on laboratory screening. Due to the rarity of this association we were obliged to report the same.ÂReferences
Zancanaro PC, Isaac AR, Garcia LT, Costa IM. Localized scleroderma in children: clinical, diagnostic and therapeutic aspects. An Bras Dermatol. 2009;84:161-72.
Peterson LS, Nelson AM, Su WP. Classification of morphea (localized scleroderma). Mayo Clin Proc. 1995;70:1068-76.
Mayes MD. Classification and epidemiology of scleroderma. Semin Cutan Med Surg. 1998;17:22-6.
Laxer RM, Zulian F. Localized scleroderma. Curr Opin Rheumatol. 2006;18:606-13.
Mourier-Clavreul MC, Rousset H, Claudy A. Sclerodermie et pathologie thyroidienne. Ann Dermatol Venereol. 1989;116:701-6.
Ghayad E, Tohme A, Haddad F et al. Scleroderma with anomalies of the thyroid function. Seven cases. Ann Med Interne (Paris). 1997;148:307-10.
Goodfield MJD, Jones SK, Veale DJ. The Connective Tissue Diseases. In: Burns T, Breathnach S, Cox N, Griffiths C, Eds. Rook’s Textbook of Dermatology, 8th edn. Oxford, UK: Wiley-Blackwell; 2010; 51.64-51.78.
Dimitrova V, Yordanova I, Gospodinov D. Generalized morphea: A case report. J IMAB. 2007;13:68-70.
Horita M, Takahashi N, Seike M, Nasu S, Takaki R. A case of primary biliary cirrhosis associated with Hashimoto’s thyroiditis, scleroderma and Sjogren’s syndrome. Intern Med. 1992;31:418-21.
Claudy AL, Segault D, Rousset H, Moulin G. Facial hemiatrophy, homolateral cervical linear sclerodema and thyroid disease. Ann Dermatol Venereol. 1992;119:543-5.
Lee HJ, Kim MY, Ha SJ, Kim JW. Two cases of morphea associated with Hashimoto’s thyroiditis. Acta Derm Venereol. 2002;82:58-78.
Fett N, Werth VP. Update on morphea: part I. Epidemiology,clinical presentation, and pathogenesis. J Am Acad Dermatol. 2011:64:217-28.
Chung L, Lin J, Furst DE, Fiorentino D. Systemic and localized scleroderma. Clin Dermatol. 2006;24:374-92.
Sampaio C, Visentin MT, Howell K et al. Morphoea. In: Harper J, Oranje A, Prose N, editors. Textbook of Pediatric Dermatology. 2nd edn. Oxford: Blackwell Publishing; 2006. p. 2020-9.
Fett N, Werth V P, Update on morphea Part II. Outcome measures and treatment. J Am Acad Dermatol. 2011;64:231-42.
