DISTRIBUTION OF CD4+ RORg-T Th17 AND CD25+ FOXP3+ Treg IN LEPROSY PATIEN WITH REVERSAL REACTION
Keywords:
CD4 RORg-T Th17, CD25 FOXP3 Treg, IL17, TGF-β, Reversal Reaction, Erythema Nodosum LeprosumAbstract
References
WHO Expert Committee on leprosy. Eight report. Geneva, World Health Organization, 2002. WHO Technical Report Series, No. 968.
Worobec SM. Current approaches and future directions in the treatment of leprosy. Trop Med. 2012;3:79-91.
Walker SL, Lockwood DNJ. (2006). The Clinical and immunological features of leprosy. Br Med Bull. 2006;77-78:103-21.
Pandhi D, Chhabra N. New Insights in The Pathogenesis of Type 1 and Type 2 Lepra Reaction. Indian J Dermatol Venereol Leprol. 2013;79:739-749.
Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007;8:345-50.
Saini C, Ramesh V, Nath I. CD4+ Th17 cells discriminate clinical types and constitute a third subset of non Th1, non Th2 T cells in human leprosy. PLoS Negl Trop Dis. 2013;7(7):e2338.
Sadhu S, Khaitan BK, Joshi B, Sengupta U, Nautiyal AK, Mitra DK. Reciprocity between regulatory T cells and Th17 cells: Relevance to polarized immunity in leprosy. PLoS Negl Trop Dis. 2016;10(1): e0004338.
Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S et al. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 2013;14:307-8.
Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012;30:531-64.
Nath I, Van Rood JJ, Mehra NK, Vaidya MC. Natural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses. Clin Exp Immunol. 1980;42:203-10.
Saini C, Siddiqui A, Ramesh V, Nath I. Leprosy reactions show increased Th17 cell activity and reduced FOXP3+ Tregs with concomitant decrease in TGF-beta and increase in IL-6. PLoS Negl Trop Dis. 2016;10(4):e0004592.
Vieira AP, Trindade MÂ, Pagliari C, Avancini J, Sakai-Valente NY, Duarte AJ et al. Development of type 2, but not type 1, leprosy reactions is associated with a severe reduction of circulating and in situ regulatory T-cells. Am J Trop Med Hyg. 2016;94:721-7.
