A case of neurofibromatosis type1 with coexisting borderline tuberculoid leprosy
Keywords:
Leprosy, neurofibromatosis, Schwann cellAbstract
Leprosy and neurofibromatosis are different entities. Both diseases present with nerve enlargement and skin lesions but the coexistence is rare. Nodules of neurofibromatosis may be mistaken for that of lepromatous leprosy and vice versa. Their simultaneous occurrence in same person may lead to diagnostic dilemma. We report a case which was at first mistaken as lepromatous leprosy. But proper history and examination aided by slit skin smear and skin biopsy for histopathological examination helped to reach the appropriate diagnosis of borderline tuberculoid leprosy associated with neurofibromatosis.References
Robert L, Charrow J. The neurofibromatoses In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ. eds. Fitzpatrick’s Dermatology in General Medicine, 7th ed. New York: McGraw Hill; 2008. P. 1331-9.
James WD, Berger TG, Elston DM, eds. Andrew’s Diseases of the Skin, 11th edn. Saunders Elsevier; 2011: 544-545.
Riccardi VM. Von Recklinghausen neurofibromatosis. N Engl J Med. 1981;305:1617-27.
Job CK. Mycobacterium leprae in nerve lesions in lepromatous leprosy. An electron microscopic study. Arch Pathol. 1970;89:195-207.
Locke S, Umlas J. Unusual rash and sensorimotor neuropathy. N Engl J Med. 1970;282:1144-52.
Ghosh S, Kundu SK. Neurofibroma and leprosy. Indian J Dermatol. 1970;15(3): 79-82.
Grover C, Lohra M, Nanda S, Reddy BSN. Leprosy with neurofibromatosis – a diagnostic dilemma. Lepr Rev. 2005;76:91-93.
Naik RP, Srinivas CR, Rao RV. Thickening of peripheral nerves in neurofibromatosis. Indian J Lepr. 1985;57:876-8.
Mittal A, Masuria BL, Gupta LK et al. Thickening of peripheral nerves in neurofibromatosis. Indian J Dermatol Venereol Leprol. 1997;63:63-4.
Khandpur S, Malhotra AK, Deepak KK, Verma KK. Neurofibromatosis I with unusual hypopigmentation masquerading as leprosy. J Assoc Physic Ind. 2004;52:1001-3.
Swift TR. Neurofibromatosis and leprosy. J Neurol Neurosurg Psychiat. 1971;34:743-9.
Angoori GR, Danturty I, Singh TNR. Borderline lepromatous leprosy with neurofibromatosis. Indian J Dermatol. 2010;55:262-4.
Karthimeyan K, Latchoumibady K, Sowmya S. Double trouble: a case of von Recklinghausen’s disease with coexistent lepromatous leprosy. J Infect Dev Ctries. 2012;6:287-9.
Joseph MS. Von Recklinghausen’s disease associated with diffuse lepromatous leprosy – a case report. Indian J Lepr. 1985;57:872-5.
Thomas J, Wilson NC, Parimalam S et al. Multiple neurofibromatosis with histoid leprosy. Int J Lepr Other Mycobact Dis. 1989;57:695-6.
Rao MV, Thappa DM, D’Souza M et al. Neurofibromatosis with pure neuritic leprosy. J Dermatol. 1997;24:799-800.
