Keloids: clinical features and management. Part I
DOI:
https://doi.org/10.66344/jpad.16.2.2006.856Keywords:
Keloid, hypertrophic scars, clinical features, managementAbstract
Keloids are benign tumours of fibrous origin which clinical ly present as firm, fesh-coloured tumours. The exact etiology is not known; nevertheless, there have been many associated dermatoses. Therapeutically, keloids have been a challenging disease and not a single effective therapy is available. The present review presents the clinical features and therapeutic update of this common malady.ÂReferences
Burton JL, Lovell CR. Disorders of connective tissue. In: Champion RH, Burton JL, Burns DA, Breathnach SM, eds. Textbook of Dermatology. Oxford: Blackwell Science; 1998. p. 2003-71.
From L, Assaad D. Neoplasms, pseudoneoplasms and hyperplasias of the dermis. In Freedberg IM, Eisen AZ, Wolff K et al., eds. Dermatology in General Medicine. New York: McGraw-Hill; 1999. p. 1161-75.
Child FJ, Fuller LC, Higging EM, Vivier DU. A study of the spectrum of skin disease occurring in a black population in South-East London. Br J Dermatol 1999; 141: 512-7.
Shaffer JJ, Taylor SC, Cook-Bolden F. Keloidal scars: a review with a critical look at theratpeutic options. J Am Acad Dermatol 2002; 46: 63-97.
Kuflik EG. Cryosurgery updated. J Am Acad Dermatol 1994; 31: 925-44.
Ragoowansi R, Paul GS, Glees JP. Treatment of keloids by surgical excision and immediate postoperative single-fraction radiotherapy. Plast Rec Sur 2003; 111: 1853-9.
Granstein RD, Rook A, Thomas J, Amento EP. A controlled trial of intralesional recombinant interferon-ï§ in the treatment of keloidal scarring. Arch Dermatol 1990; 126: 1295-1302.
Graham FG. Cryosurgery. In: Freedberg IM, Eisen AZ, Wolff K et al., eds. Dermatology in General Medicine. New York: McGraw-Hill; 1999. p. 2980-7.
Layton AM, Yip T, Cunliffe WJ. A comparison of intralesional triamcinolone and cryosurgery in the treatment of acne keloids. Br J Dermatol 1994; 130: 498-501.
Dawber R, Colves G, Jackson A, eds. Cutaneous Cryosurgery. London: Martin Dunitz; 1997.
Brody GS. Keloids and hypertrophic scars. Plast Reconstr Surg 1990; 86: 804.
Heenan PJ. Tumors of the fibrous tissue involving the skin. In Elder D, Elenitsas R, Jaworsky C, Johnson B, eds. Lever’s Histopathology of the Skin. New York: Lipincott-Raven; 1997. p. 847-87.
Cobbold CA. The role of nitric oxide in the formation of keloid and hypertrophic lesions. Med Hypotheses 2001; 57: 497-502.
Naitoh M, Hosokawa N, Kubota H et al. Upregulation of HSP47 and collagen type III in the dermal firbotic disease, keloid. Biochem Biophys Res Commun 2001; 280: 1316-22.
Luo S, Benathan M, Raffoul W et al. Abnormal balance between proliferation and apoptotic cell death in firboblasts derived from keloid lesions. Plast Recon Sur 2001; 107: 87-96.
Rodland KD, Muldoon LL, Magun BE. Cellular mechanisms of TGF-ï¢ action. J Invest Dermatol 1990; 94: 33S-40S.
Heckmann M, Grill BCA, Hein R, Kriegs T. Biphasic effects of interleukin-1ï¡ on dermal fibroblasts: enhancement of chemotactic responsiveness at low concentrations and of mRNA expression for collagenase at high concentrations. J Invest Dermatol 1993; 100: 780-4.
Hebda PA, Collins MA, Tharp MD. Mast cell and myofibroblast in wound healing. Dermatol Clin 1993; 11: 685-96.
Garner WL, Karmiol S, Rodriguez JL et al. Phenotypic difference in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts. J Invest Dermatol 1993; 101: 875-9.
Lim IJ, Phan TT, Bay BH et al. Fibroblasts co-cultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloid like manner. Am J Physiol Cell Physiol 2002; 283: C212-22.
Meyer LJM, Stern R. Age dependent changes of hyaluronan in human skin. J Invest Dermatol 1994; 102: 385-9.
Murray JC. Scars and keloid. Dermatol Clin 1993; 11: 697-708.
Tuan TL, Huayang WU, Eunice Y et al. Increased plasminogen activator inhibitor-1 in keloid fibroblasts may account for their elevated collagen accumulation in fibrin gel cultures. Am J Pathol 2003; 162: 1579-89.
Peltonen J, Hsiao LL, Jaakkola S et al. Activation of collagen gene expression in keloids: co-localization of type-I and VI collagen and transforming growth factor ï¢1 mRNA. J Invest Dermatol 1991; 97: 240-8.
Richard AFC, Denver CO. Cutaneous tissue repair. Basic biologic consideration. Am Acad Dermatol 1985; 13: 710-25.
Pettinger DA, Yager DR, Diegelmann RF, Cohen IK. The effect of TGF-ï¢ on keloid fibroblast proliferation and collagen synthesis. Plast Reconr Surg 1996; 98: 827-33.
Glat PM, Longaker MT. Wound healing. In: Aston SJ, Beasley RW, Thome CHM. Grabb and Smith’s Plastic Surgery, 5th edn. Philadelphia: Lippincott-Raven; 1997. p. 3-12.
Lim IJ, Phan TT, Tan WTL, Longaker MT. Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in vitro. Plast Recon Surg 2001; 107: 797-808.
Datubo-Brown DD. Keloids: a review of the literature. Br J Plast Surg 1990; 43: 70-7.
Tsao SS, Dover JS, Arndt KA, Kaminer MS. Scar management: Keloid, hypertrophic, atrophic and acne scars. Semin Cutan Med Surg 2002; 21: 46-75.
Niessen FB, Spaumen PH, Schalkwij KJ et al. On the nature of hypertrophic scars and keloids: a review Plast Recon Surg 1999; 104: 1435-58.
Gold MH. A controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. J Am Acad Dermatol 1994; 30: 56-7.
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