Assessment of hypothyroidism in diffuse nonscarring alopecia
DOI:
https://doi.org/10.66344/jpad.16.1.2006.841Keywords:
Alopecia, hypothyroidism, triidothyronine, tetraidothyronine, thyroid stimulating hormoneAbstract
Background Alopecia, clinically as well as etiologically, is a heterogeneous group. Several hormonal etiologies may cause alopecia including hyperthyroidism, hypothyroidism etc. Thyroid diseases show a wide range of clinical signs in skin, hair and nails. Several reports document a significant correlation between thyroid diseases especially hypothyroidism with alopecia. Thyroid function test is one of the useful indices to assess the cause of alopecia. Objective The aim of our study was to evaluate the frequency of alopecia in hypothyroid cases by performing the thyroid function tests (T3, T4, TSH). Patients and methods Twenty diagnosed patients of hypothyroidism were assessed for alopecia (according to the Hamilton and Norwood grading scale) and thyroid function tests. 20 healthy controls were recruited for comparison.  Results Out of 20 hypothyroid patients, 10 (50%) showed alopecia of variable grades. On laboratory investigations, significantly decreased levels of T3 and increased levels of TSH were noticed. Conclusions Alopecia is quite frequent in hypothyroid patients. Similarly, thyroid profile is one of the useful diagnostic index for screening patients with alopecia. ÂReferences
de Berker DAR, Messenger AG, Sinclair RD. Disorders of hair. In: Burns T, Breathnach S, Cox N, Griffiths C, eds. Rook’s Textbook of Dermatology,7th edn. London: Blackwell Science; 2004. p. 63.1-63.120.
Heymann WR. Autoimmune thyroid diseases: etiology, pathogenesis, and dermatologic manifestations. J Am Acad Dermatol 2003; 48: 641-59.
Niepomniszcze H, Amad RH. Skin disorders and thyroid diseases. J Endocrinol Invest 2001; 24: 628-38.
Leye A, Pouye A, Fall S et al. Non iatrogenic primary hypothyrodism in adults at Le Dantec Hospital: clinical features, diagnosis and treatment. Review of 19 cases. Dakar Med 2004; 49: 110-3.
Sidibe el-H, Fall L, Sow AM. Clinical characteristics of primary hypothyroidism in Dakar. A propos of 37 cases. Sante 1997; 7: 291-4.
Djrolo F, Houngbe F, Attolou V et al. Hypothyroidism: clinical and etiological aspects in Cotonou (Republic of Benin). Sante 2001; 11: 245-9.
Messenger AG. Thyroid hormone and hair growth. Br J Dermatol 2000; 142: 633-4.
Maurel D, Coutant C, Boissin J. Thyroid and gonadal regulation of hair growth during the seasonal moult in the male European badger. Meles meles L. Gen Comp Endocrinol 1987; 65: 317-27.
Schell H, Kiesewetter F, Seidel C et al. Cell cycle kinetics of human scalp hair bulbs in thyroid disorders determined by DNA flow cytometry. Dermatologica 1991; 182: 23-6.
Downloads
Published
How to Cite
Issue
Section
License
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.