The guardian of genome: p53

Authors

  • Shahbaz A. Janjua

References

Harris CC, Hollstein M. Clinical

implications of the p53 tumorsuppressor

gene. N Engl J Med 1993;

: 1318-27.

Lane DP, Crawford LV. T antigen is

bound to a host protein in SV40-

transformed cells. Nature 1979; 278:

-3.

Linzer DI, Levine AJ. Characterization

of a 54K dalton cellular SV40 tumor

antigen present in SV40-transformed

cells and uninfected embryonal

carcinoma cells. Cell 1979; 17: 43-52.

Levine AJ, Momand J, Finlay CA. The

p53 tumour suppressor gene. Nature

; 351: 453-6.

Hollstein M, Sidransky D, Vogelstein

B, Harris CC. p53 Mutations in human

cancers. Science 1991; 253: 49-53.

Greenblatt MS, Bennett WP, Hollstein

M, Harris CC. Mutations in p53 tumor

suppression gene: clues to cancer

etiology and molecular pathogenesis.

Cancer Res. 1994; 54: 4855-78.

McNutt NS, Saenz-Santamaria C,

Volkenandt M et al. Abnormalities of

p53 protein expression in cutaneous

disorders. Arch Dermatol 1994; 130:

-32.

Gasparro FP. p53 in dermatology. Arch

Dermatol 1998; 134: 1029-32.

Dittmer D, Pati S, Zambetti G et al.

Gain of function mutations in p53. Nat

Genet 1993; 4: 42-6.

Brash DE, Rudolph JA, Simon JA et al.

A role for sunlight in skin cancer: UVinduced

p53 mutations in squamous cell

carcinoma. Proc Natl Acad Sci U S A

; 88: 10124-8.

Drobetsky EA, Grosovsky AJ,

Glickman BW. The specificity of UVinduced

mutations at an endogenous

locus in mammalian cells. Proc Natl

Acad Sci U S A 1987; 84: 9103-7.

Saed GM, Ladin D, Olson J et al.

Analysis of p53 gene mutations in

keloids using polymerase chain

reaction-based single-strand

conformational polymorphism and

DNA sequencing. Arch Dermatol 1998;

: 963-7.

Firestein GS, Nguyen K, Aupperle KR

et al Apoptosis in rheumatoid arthritis:

p53 overexpression in rheumatoid

arthritis synovium. Am J Pathol 1996;

: 2143-51.

Chin KV, Ueda K, Pastan I, Gottesman

MM. Modulation of activity of the

promoter of the human MDR1 gene by

Ras and p53. Science 1992; 255: 459-

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Published

2017-01-03

How to Cite

1.
Janjua SA. The guardian of genome: p53. J Pak Assoc Dermatol [Internet]. 2017Jan.3 [cited 2026Feb.26];14(3):107-9. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/794

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