Comparative efficacy of griseofulvin and fluconazole in the treatment of tinea capitis
Keywords:
Tinea capitis, griseofulvin, fluconazoleAbstract
Background Tinea capitis is caused by different species of dermatophytes particularlyMicrosporum and Trichophyton. Children are affected predominantly. Many systemic drugse.g. griseofulvin, fluconazole, itraconazole, terbinafine, ketoconazoe etc are available forthe treatment of tinea capitis.Objectives To compare the efficacy of griseofulvin and fluconazole in the treatment oftinea capitis.Patients and methods A total of 50 patients of age group 2-15 years were selected for thestudy. The cases were diagnosed clinically and confirmed by Wood’s lamp examination,KOH microscopy and culture. The patients were divided into two equal groups. Group Awas given griseofulvin and group B was given fluconazole for a period of two months.Topical adjuvant therapy econazole nitrate was given in both groups. The patients werefollowed up at 2 weekly interval for clinical response and Wood’s lamp examination andfinally KOH microscopy and culture.Results In group A clinical response was 84% and mycological response was 68% whereasin group B clinical response was 68% and mycological response was 56%.Conclusion The present study showed that griseofulvin is more effective in the treatment ofnoninflammatory type of tinea capitis than fluconazole.References
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