Treatment of Schamberg's disease with pentoxifylline - therapeutic trial

Authors

  • Rostami Mogaddam Majid Department of Dermatology, Ardebil university of Medical Sciences, Iran

DOI:

https://doi.org/10.66344/jpad.v18i2.574

Keywords:

pentoxifylline, Schamberg’s disease

Abstract

Thirty patients with Schamberg's disease were started on pentoxifylline (400 mg three times daily) for a period of 9 weeks. Improvement was assessed at 3 weekly intervals by two observers independently and graded as mild (<25%), moderate (25-50%) and marked (>50%). Marked improvement was observed in 15/30 (50%) patients. We conclude that pentoxifylline should be considered as first line therapy in all patients with Schamberg's disease.

References

1. Champion RH. Purpura. In: Champion RH, Burton JL, Burns DA, Breathnach SM, eds. Textbook of Dermatology, Vol III, 6th edn. London: Blackwell Scientific Publications; 1998. p. 2149-2151.

2. Kano Y, Hiroyama K, Shiohra T Successful treatment of Schamberg's disease with pentoxifylline. J Am Acad Dermatol 1997; 36: 827-30.

3. Samlaska CP, Winfield EA. Pentoxifylline. J Am Acad Dermatol 1994; 30: 603-621.

4. Ely H. Is pentoxifylline the drug of the decade? J Am Acad Dermatol 1994; 30: 603-40.

5. Schwarz A, Arragne Y, Simson M et al. Pentoxifylline suppresses UVB induced cutokine release by keratinocytes (abstract). J Invest Dermatol 1993; 101: 388.

Downloads

Published

24.12.2016

Issue

Section

Original Articles

How to Cite

1.
Treatment of Schamberg’s disease with pentoxifylline - therapeutic trial. J Pak Assoc Dermatol [Internet]. 2016 Dec. 24 [cited 2026 Aug. 3];18(2):97-9. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/574