Induction of depigmentation in a universal vitiligo patient with combination of cryotherapy and phenol
DOI:
https://doi.org/10.66344/jpad.19.2.2009.522Keywords:
Universal vitiligo, cryotherapy, phenolAbstract
A 13-year-old boy presented with vitiligo for last 5 years, which had slowly progressed to universal type except for a few macules on face. Topical monobenzylether of hydroquinone (MBEH) 20%, liquid nitrogen cryotherapy, phenol 88% and frequency-doubled Nd:YAG Q-switched laser had been used separately without any benefit. To resolve this problem, a combination of liquid nitrogen cryotherapy along with phenol 88% was planned. After single session, the patient responded to this method with complete depigmentation without any complication. We suggest that the combination of liquid nitrogen cryotherapy and phenol 88% for depigmentation of remaining normal pigmented skin in universal vitiligo, can be safe and cost-effective.References
Ortonne JP, Bahadoran P, Fitzpatrick TB et
al. Hypomelanoses and hypermelanoses. In: Freedberg IM, Eisen AZ, Wolff K et al., eds. Fitzpatrick’s Dermatology In General Medicine, Vol 1,.6th edn. New York: MacGraw Hill; 2004. p. 830-47.
James WD, Berger TG, Elston DM, eds. Andrew’s Disease of The Skin: Clinical Dermatology, 10th edn. Philadelphia: Saunders Elsevier; 2006. p. 860-2.
Boissy RE, Nordlund JJ. Vitiligo. In: Arndt KA, Leboit PE, Robinson JK, Wintroub BU, eds. Cutaneous Medicine and Surgery, Vol 2, 1st edn. Philadelphia: Saunders Elsevier; 1996. p. 1210-8.
Ortonne JP, Passeron T. Melanin pigmentary disorders: treatment update. Dermatol Clin 2005; 23: 209-26.
Njoo MD, Vodegel RM, Westerhof W. Depigmentation therapy in vitiligo universalis with topical 4-methoxyphenol and the Q-switched ruby laser. J Am Acad Dermatol 2000; 42: 760-9.
Thissen M. Laser treatment for further depigmentation in vitiligo. Int J Dermatol 1997; 36: 386-8.
Radmanesh M. Depigmentation of the normally pigmented patches in universal vitiligo patients by cryotherapy. J Eur Acad Dermatol Venereol 2000; 14: 149-52.
Mosher DB, Parish JA, Fitzpatrick TB. Monobenzylether of hydroquinone; A retrospective study of treatment of 18 vitiligo patients and review of literature. Br J Dermatol 1977; 97: 669-79.
Oakley AM. Rapid repigmentation after depigmentation therapy: vitiligo treated with monobenzyl ether of hydroquinone. Australas J Dermatol 1996; 37: 96-8.
Roenigk RK. Facial chemical peel: In: Baran R, Maibach HI, eds. Textbook of Cosmetic Dermatology, 2nd edn. London: Martin Daunitz; 1998. p. 585-94.
Angelini E, Marinaro C, Carrozo AM. Allergic contact dermatitis of the lip margins from para-tertiary-butylphenol in a lip liner. Contact Dermatitis 1993; 28: 146-8.
Coleman KM, Coleman WP. Complication: In: Rubin MG, Dover JS, Alam M, editors . Chemical Peels, 1st edn. Philadelphia: Elsevier & Saunders; 2006. p. 171-85.
Mysore V. Use of phenol to induce pigmentation in vitiligo. J Cosmet Dermatol 2002; 1: 99-100.
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