Pigmentary mosaicism: A report of five cases from a tertiary care hospital in South India

Authors

  • Rajkiran Takharya Department of Dermatology, Manipal Tata Medical College, India
  • Jude Ernest Dileep Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India
  • Damayandhi Kaliyaperumal Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India
  • Divya Mani Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India
  • Gayathri Jayabalan Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India
  • Sanjay Kumar Menon Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India

DOI:

https://doi.org/10.66344/jpad.34.3.2024.2523

Keywords:

Hypopigmentation, Hyperpigmentation, Lines of Blaschko, Pigmentary mosaicism

Abstract

Pigmentary mosaicism is a term that describes various patterns of segmental pigmentation disorders based on genetic heterogenicity of skin cells. Pigmentary mosaicism is a collective term, which comprises phenotypes represented by mosaic hypo- and/ or hyperpigmentation in the form of whorls, patchy, streaks or more bizarre skin configurations. Melanocyte precursors are neural crest derived and migrate through the Dorso-lateral pathway during embryogenesis. This group of disorders may be associated with or without systemic abnormalities. In a considerable number of cases, pigmentary mosaicism is observed alongside extracutaneous oddities generally affecting the musculoskeletal system and central nervous system. Pigmentary mosaicism includes a variety of inherited, patterned pigmentary dermatoses which have been described using various terms such as hypo melanosis of Ito, linear and whorled nevoid hypermelanosis, phylloid hypo- and hypermelanoses and pigmentary mosaicism of both hypopigmented and hyperpigmented type.  Here, we present a series of 5 cases of pigmentary mosaicism in a single report.

Author Biographies

Rajkiran Takharya, Department of Dermatology, Manipal Tata Medical College, India

Assistant Professor

Jude Ernest Dileep, Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India

Associate Professor

Damayandhi Kaliyaperumal, Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India

Associate Professor

Divya Mani, Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India

Senior Resident

Gayathri Jayabalan, Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India

Senior Resident

Sanjay Kumar Menon, Department of Dermatology, Aarupadai Veedu Medical College, Pondicherry, India

3rd year Postgraduate

References

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Published

2024-07-02

How to Cite

1.
Takharya R, Dileep JE, Kaliyaperumal D, Mani D, Jayabalan G, Menon SK. Pigmentary mosaicism: A report of five cases from a tertiary care hospital in South India. J Pak Assoc Dermatol [Internet]. 2024Jul.2 [cited 2026Apr.22];34(3):761-4. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2523

Issue

Vol. 34 No. 3 (2024): July-September

Section

Case Reports

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