Can Ki-67 immunohistochemistry marker differentiate mycosis fungoides from cutaneous lichen planus?

Authors

  • Mazaher Ramezani Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Kambiz Kamyab Hesari
  • Negar Ramezanizoorab
  • Masoud Sadeghi
  • Mansour Rezaei
  • Sedigheh Khazaei

DOI:

https://doi.org/10.66344/jpad.32.4.2022.2019

Abstract

Objective: The purpose of this study was to evaluate the immunohistochemical expression of Ki-67 marker in MF and LP lesions. Methods: This cross-sectional analytical study included patients undergoing skin biopsy with their first clinical and pathologic diagnosis of MF and cutaneous LP by Ki-67 immunohistochemistry (IHC). Sixty-two patients with cutaneous LP and MF were studied in two groups of 39 and 23 patients, respectively. Linear regression was used for the possible correlation between age and Ki-67 index (%) in both LP and MF patients. Results: The results of this study found that Ki-67 was expressed in 100% of both MF and LP lesions, and no significant correlation was found between Ki-67 and either of the two types of diseases (p = 0.606). The results of this study also showed that expression of Ki-67 marker was more than 25% in both types of diseases in 70% of the population, which seems not to be directly related to malignancy. Conclusions: IHC with proliferative marker Ki-67 is not a valuable technique for differentiating cutaneous LP from MF lesions alone.

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Published

2022-12-08

How to Cite

1.
Ramezani M, Kamyab Hesari K, Ramezanizoorab N, Sadeghi M, Rezaei M, Khazaei S. Can Ki-67 immunohistochemistry marker differentiate mycosis fungoides from cutaneous lichen planus?. J Pak Assoc Dermatol [Internet]. 2022Dec.8 [cited 2026Apr.12];32(4):676-82. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2019

Issue

Vol. 32 No. 4 (2022): October - December

Section

Original Articles

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Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.

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