Correlation between transepidermal water loss with proinflammatory cytokines in non-aging and aging group

Authors

  • Winawati Eka Putri Universitas Nahdlatul Ulama Surabaya
  • Meidyta Sinantryana
  • Hotimah Masdan Salim

DOI:

https://doi.org/10.66344/jpad.31.3.2021.1620

Abstract

Background  Aging is a complex process and makes progressive loss of functional capacity of organ such as skin. Transepidermal water loss represents changes in skin permeability which happen in aging. There is an imbalance of immune system in aging. It can cause condition called inflammaging. Proinflammatory cytokines such as IL-6 and TNF-α were elevated in skin aging.  Purpose: This study aims to find correlation between TEWL and proinflammatory cytokines in non-aging and aging.  Methods  This research is an analytic observational study with cross sectional design. The IL-6 and TNF-α level were measured by using sandwich ELISA technique. TEWL was measured by Tewameter.  Results The mean value of IL-6 and TNF-α in both non-aging and aging group showed no significant difference. The TEWL in aging and non-aging group showed no statistically significant difference with IL-6 and TNF-α.   Conclusion  There was no significant relationship between TEWL and proinflammatory cytokines in non-aging and aging group.  

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Published

2022-04-10

How to Cite

1.
Putri WE, Sinantryana M, Salim HM. Correlation between transepidermal water loss with proinflammatory cytokines in non-aging and aging group. J Pak Assoc Dermatol [Internet]. 2022Apr.10 [cited 2026May4];31(3):353-7. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1620

Issue

Vol. 31 No. 3 (2021): July - September

Section

Original Articles

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Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.

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