Correlation between transepidermal water loss with proinflammatory cytokines in non-aging and aging group
DOI:
https://doi.org/10.66344/jpad.v31i3.1620Abstract
Background Aging is a complex process and makes progressive loss of functional capacity of organ such as skin. Transepidermal water loss represents changes in skin permeability which happen in aging. There is an imbalance of immune system in aging. It can cause condition called inflammaging. Proinflammatory cytokines such as IL-6 and TNF-α were elevated in skin aging.
Purpose: This study aims to find correlation between TEWL and proinflammatory cytokines in non-aging and aging.
Methods This research is an analytic observational study with cross sectional design. The IL-6 and TNF-α level were measured by using sandwich ELISA technique. TEWL was measured by Tewameter.
Results The mean value of IL-6 and TNF-α in both non-aging and aging group showed no significant difference. The TEWL in aging and non-aging group showed no statistically significant difference with IL-6 and TNF-α.
Conclusion There was no significant relationship between TEWL and proinflammatory cytokines in non-aging and aging group.
References
1. Chung, J., Cho, S. and Kang, S. (2004) ‘Why Does the Skin Age? Intrinsic Aging, Photoaging, and Their Pathophysiology’, in Rigel, D. et al. (eds). New York: Marcel Dekker, Inc.
2. Assaf, H., Adly, M. and Hussein, M. (2010) ‘Aging and Intrinsic Aging: Pathogenesis and Manifestations’, in Farage, M., Miler, K., and Maibach, H. (eds) Textbook of Aging Skin. Berlin: Springer.
3. Minciullo, P. L. et al. (2016) ‘Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity’, Archivum Immunologiae et Therapiae Experimentalis. Springer International Publishing, 64(2), pp. 111–126. doi: 10.1007/s00005-015-0377-3.
4. Garg, C., Khurana, P. and Garg, M. Molecular mechanisms of skin photoaging and plant inhibitors. Int J Green Pharm (IJGP).2017;11(2):217–32.
5. Kovaiou, R. D., Weinberger, B. and Grubeck-Loebenstein, B. Aging and the immune system. Clinical Immunology. Elsevier, pp. 503–511.
6. Galzote C and Suero M. 2006. Noninvasive Evaluation of Skin in the Cosmetic Industry. In Walters KA and roberts MS (eds). Dermatologic, Cosmeceutic, and Cosmetic Development Therapeutic and Novel Approaches. New York: Informa healthcare
7. Alikhan A, Wilhelm KP, Alikhan FS, Maibach HI. 2010. Transepidermal Water loss and Aging. In Farage MA, Miller KW, Maibach HI (eds). Textbook of Aging Skin. Berlin: Springer
8. Wang Z, Man MQ, Li T, Elias PM, Mauro TM. Aging-associated alterations in epidermal function and their clinical significance. Aging.2020;12(6):5551-65.
9. Mansouri, P. et al. (2014) ‘Skin aging and immune system’, in Massoud, A. and Rezaei, N. (eds) Immunology of Aging. New York: Springer, pp. 339–68.
10. Simon, A. K., Hollander, G. A. and McMichael, A. Evolution of the immune system in humans from infancy to old age. Proc Royal Soc B.2015;282(1821). doi: 10.1098/rspb.2014.3085.
11. Brüünsgaard, H. and Pedersen, B. K. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am. 2003; 23(1):15–39.
doi: 10.1016/S0889-8561(02)00056-5.
12. Milan-Mattos, J. C. et al. Effects of natural aging and gender on pro-inflammatory markers. Braz J Med Biol Res.2019;52(9):1-10.
doi: 10.1590/1414-431x20198392.
13. Kim HO, Kim HS, Youn JC, Shin EC, Park S. Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays. J Transl Med.2011;9:113.
14. Wu, D. et al. Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue’, J Immunol.2007; 179(7):4829–39.
doi: 10.4049/jimmunol.179.7.4829.
15. Ye, L. et al. Topical applications of an emollient reduce circulating pro-inflammatory cytokine levels in chronically aged humans: a pilot clinical study. J Eur Acad Dermatol Venereol.2019;33(11): 2197–2201. doi: 10.1111/jdv.15540.
16. Lumentut, A. R., Marunduh, S. and Rampengan, J. J. V. (2015) ‘Profil TNF- α pada orang lanjut usia di Panti Wredha Bethania Lembean. Jurnal e-Biomedik (eBm).2015;3(2):644-47.
Downloads
Published
Issue
Section
License
Copyright (c) 2021 Winawati Eka Putri, Meidyta Sinantryana, Hotimah Masdan Salim
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
