Efficacy and safety of blue light versus 4% topical benzoyl peroxide in mild to moderate acne
Keywords:
Benzoyl peroxide, acnes, blue lightAbstract
Objective To determine the efficacy and safety of blue light in comparison with 4% topical benzoyl peroxide (BPO) in mild to moderate acne. Methods This randomized controlled trial, carried out in the Department of Dermatology at Services Institute of Medical Sciences/Services Hospital, Lahore, included 124 patients age ranging from 14-35 years having mild to moderate acne. Patients were randomized to receive blue light therapy (group I) or topical 4% BPO twice daily (group II). Efficacy was determined at week 8 by comparing % reduction in number of lesions. Side effects were noted during treatment period. Results Total 124 patients were randomly divided into two groups. Group I, 62 (50%) patients were treated with blue light therapy and group B, 62 (50%) patients were treated with 4% topical BPO. 52 patients were male (41.9%) whereas 72 were females (58.1%). The mean age of the patient was 23.02 ± 6.3 years. The efficacy of the treatment in term of % reduction in the number of lesions was more in blue light group as compared to 4% topical BPO group, (76% vs. 60%), P <0.05. Blue light group was safer as compared to 4% topical BPO group (100% vs. 91%). Conclusion Blue light is more effective and safe therapy for mild to moderate acne patients as compared to 4% topical benzoyl peroxide.References
Cunliffe WJ, Goulden V. Phototherapy and acne vulgaris. Br J Dermatol. 2000;142:855-6.
Thomas S. Topical antibiotics and benzoyl peroxide for treatment of acne. Am Fam Physician, 2003 [online]. Available at: http://www.aafp.org/afp/2012/1015/p 734.html, July 1; 88(1).
Hasibur MR, Meraj Z. Combination of low-dose isotretinoin and pulsed oral azithromycin for maximizing efficacy of acne treatment. Mymensingh Med J. 2013;22(1):42-8.
Salvaggio HL, Zaenglein AL Examining the use of oral contraceptives in the management of acne. Int J Womens Health. 2010;2:69-76.
Pierard-Franchimont C, Goffin V, Decroix J, Pierard GE. A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Skin Pharmacol Appl Skin Physiol. 2014;15:434-41.
Kleinpenning MM, Smits T, Frunt HM, Van Erp PE, Vande Kerkhof PC, Gerritson RM. Clinical and histological effects of blue light on normal skin. Photodermatol Photoimmunol Photomed. 2010;26:16-21.
Grove G, Zerweck C, Gwazdauskas J. Tolerability and irritation potential of four topical acne regimens in healthy subjects. J Drugs Dermatol. 2013;12:644-9.
Wheeland RG, Koreck A. Safety and effectiveness of a new blue light device for the self treatment of mild to moderate acnes. J Clin Aesthet Dermatol. 2012;5:25-31.
Collier CN, Harper JC, Cantrell WC, Wang W, Foster KW et al. The prevalence of acne in adults 20 years and older. J Am Acad Dermatol. 2008;58:56-9.
de Arruda LHF, Kodani V, Filho AB, Mazzaro CB. A Prospective randomized, open and comparative study to evaluate the safety and efficacy of blue light treatment versus a topical benzoyl peroxide 5% formulation in patients with acne grade II and III. An Bras Dermatol. 2009;84:463-8.
Shalita AR, Cunningham WJ, Leyden JJ, Pochi PE, Strauss JS. Isotretinoin treatment of acne and related disorders: an update. J Am Acad Dermatol. 1983;9:629-38.
Ammad S, Gonzales M, Edwards C, Finlay AY, Mills C. An assessment of the efficacy of blue light phototherapy in the treatment of acne vulgaris. J Cosmet Dermatol. 2008;7:180-8.
Omi T, Bjerring P, Sato S, Kawana S, Hankins RW, Honda M. 420 nm intense continuous light therapy for acne. J Cosmet Laser Ther. 2004;6:156-61.
Gold MH, Sensing W, Biron JA. Clinical efficacy of home-use blue-light therapy for mild-to moderate acne. J Cosmet Laser Ther. 2011;13:308-14.
Babaeinejad SH, Fouladi RF. The efficacy, safety and tolerability of adapalene versus benzoyl peroxide in the treatment of mild acne vulgaris: a randomized trial. J Drugs Dermatol. 2013;12:1033-8.
Kawashima M, Hashimoto H, Alio Sáenz AB, Ono M, Yamada M. Is benzoyl peroxide 3% topical gel effective and safe in the treatment of acne vulgaris in Japanese patients? A multicenter, randomized, double-blind, vehicle-controlled, parallel-group study. J Dermatol. 2014;41:795-801.