Zinc: An overview and therapeutic uses in dermatology

Dr. Arfan-ul-Bari, Simeen Ber Rehman

Abstract


Zinc is an essential component of various important enzymes in our body and its deficiency causes multi-enzyme defects and multisystemic disease. It ranks with biotin as a truly essential element in both cutaneous health and disease. Zinc deficiency may explain alopecia, ulcers, infections and a host of strange unexplainable skin changes.


Full Text:

PDF

References


Sandstead HR. Understanding zinc: recent observations and interpretations. J Lab Clin Med 1994; 124: 322-7.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2001.

Solomons NW. Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity. Nutr Rev 1998; 56: 27-8.

Prasad AS. Zinc: an overview. Nutrition 1995; 11: 93-9.

Heyneman CA. Zinc deficiency and taste disorders. Ann Pharmacother 1996; 30: 186-7.

Prasad AS, Beck FW, Grabowski SM et al. Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. Proc Soc Am Physicians 1997; 109: 68-77.

Simmer K, Thompson RP. Zinc in the fetus and newborn. Acta Paediatr Scand Suppl 1985; 319: 158-63.

Fabris N, Mocchegiani E. Zinc, human diseases and aging. Aging (Milano) 1995; 7: 77-93.

Anderson RA, Roussel AM, Zouari N et al. Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. J Am CoIl Nutr 2001; 20: 212-8.

Hambidge KM. Mild zinc deficiency in human subjects. In: Mills CF, ed. Zinc in human biology. New York: Springer-Verlag; 1989. p. 281-96.

Naber TH, van den Hamer CJ, Baadenhuysen H, Jansen JB. The value of methods to determine zinc deficiency in patients with Crohn’s disease. Scand J Gastroenterol 1998; 33: 514-23.

King JC, Keen CL. Zinc. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern nutrition in health and disease, 9th edn. Baltimore: Williams & Wilkins; 1999. p. 223-39.

Ploysangam A, Falciglia GA, Brehm BJ. Effect of marginal zinc deficiency on human growth and development. J Trop Pediatr 1997; 43: 192-8.

Nishi Y. Zinc and growth. J Am Coll Nutr 1996; 15: 340-4.

Gordon KF, Gordon RC, Passal DB. Zinc metabolism: basic, clinical, and behavioral aspects. J Pediatr 1981; 9: 341-9.

Murray MT. The healing power of foods. Rocklin: CN Prima Publishing; 1993.

US Department of Agriculture, Agricultural Research Service, 2001. United States Department of Agriculture Nutrient Database for Standard Reference, Release 14. Nutrient Data Laboratory Home Page, http://www.nal.usda.gov/fnic/foodcomp.

Dietary Guidelines Advisory Committee, Agricultural Research Service, United States Department of Agriculture (USDA). HG Bulletin No. 232, 2000.

Sandstrom B. Bioavailability of zinc. Eur J Clin Nutr 1997; 51 (Suppl 1): SI7-S19.

Whittaker P. Iron and zinc interactions in humans. Am J Clin Nutr 1998; 68: 442S-446S.

Lewis MR, Kokan L. Zinc gluconate: acute ingestion. J Toxicol Clin Toxicol 1998; 33: 99-101.

Hooper PL, Visconti L, Garry PI, Johnson GE. Zinc lowers high-density lipoprotein cholesterol levels. J Am Med Assoc 1980; 244: 1960-1.

Brouwers JR. Drug interactions with quinolone antibacterials. Drug Saf 1992; 7: 268-81.

Dendrinou-Samara C, Tsotsou G, Ekateriniadou E et al. Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions. J Inorg Biochem 1998; 71: 171-9.

Golik A, Zaidenstein R, Dishi V et al. Effects of captopril and enalapril on zinc metabolism in hypertensive patients. J Am Col1 Nutr 1998; 17: 75-8.

Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976; 11: 45-54.

Otomo S, Sasajima M, Ohzeki M, Tanaka I. Effects of D-penicillamine on vitamin B6 and metal ions in rats [in Japanese]. Njppon Y Agurigaku Zsshi 1980; 76: 1-13.

Fortes C, Forastiere F, Agabiti N et al. The effect of zinc and vitamin A supplementation on immune response in an older population. J Am Geriatr Soc 1998; 46: 19-26.

Garland ML, Hagmeyer KO. The role of zinc lozenges in treatment of the common cold. Ann Pharmacother 1998; 32: 63-9.

Girodon F, Lombard M, Galan P et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997; 41: 98-107.

Prasad AS, Beck FW, Kaplan J et al. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD). Am J Hematol 1999; 61:194-202.

Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998; 68: 447S-63S.

Black RE. Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. Am J Clin Nutr 1998; 68: 476S-79S.

Beck FW, Prasad AS, Kaplan J et al. Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Physiol 1997; 272: E1002-7.

De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J Nutr 1998; 128: 797¬-803.

Dreno B, Amblard P, Agache P et al. Low doses of zinc gluconate for inflammatory acne. Acta Derm Venereol 1989; 69: 541-3.

Dreno B, Trossaert M, Boiteau HL, Litoux P. Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. Acta Derm Venereol 1992; 73: 250-2.

Krowchuk DP. Treating acne. A practical guide. Med Clin North Am 2000; 84: 811-28.

Meynadier 1. Efficacy and safety study of two zinc gluconate regimens in the treatment of inflammatory acne. Eur J Dermatol 2000; 10: 269-73.

Papageorgiou PP, Chu AC. Chloroxylenol and zinc oxide containing cream (Nels cream®) vs. 5% benzoyl peroxide cream in the treatment of acne vulgaris. A double-blind, randomized, controlled trial. Clin Exp Dermatol 2000; 25: 16-20.

Toyoda M, Morohashi M. An overview of topical antibiotics for acne treatment. Dermatology 1998; 196: 130-4.

Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001; 7: 49-56.

Walravens FA, Hambidge KM, Neldner KH. Zinc metabolism in acrodermatitis enteropathica. J Pediatr 1978; 93: 71-3.

Der Kaloustian VM, Musallam SS, Sanjad SA et al. Oral treatment of acrodermatitis enteropathica with zinc sulfate. Am J Dis Child 1976; 130: 421-3.

Leupold D, Poley JR, Meigel WN. Zinc therapy in acrodermatitis enteropathica. Helv Paediatr Acta 1976; 31: 109-15.

Anderson I. Zinc as an aid to healing. Nurs Times 1995; 91: 68-70.


Refbacks

  • There are currently no refbacks.


ISSN: 1560-9014