Characteristic and Clinical Relevance of Atopic Dermatitis Patients with Positive Skin Prick Test to House Dust Mites: an Indonesian Retrospective Study
Keywords:
Atopic Dermatitis, Aeroallergen, Human and Disease, House Dust Mites, Skin Prick TestAbstract
Background Atopic dermatitis (AD) is a multifactorial, chronic-relapsing inflammatory skin disease that could impair quality of life. House dust mite (HDM), as the most frequent aeroallergen in Asia, has been shown as a precipitating factor that exacerbates AD. This study aims to analyze the characteristics and clinical relevance of AD caused by HDM in Surabaya, Indonesia. Methods This was retrospective study of 50 patients with AD who had tested for skin prick test (SPT) of inhalant (HDM), and food (shrimp, chicken, and cow’s milk) allergens in Dermatology and Venereology Outpatient Clinic at Dr Soetomo General Academic Hospital, Surabaya, Indonesia (2016-2020). The subjects were divided into 2 groups, subjects with positive and negative SPT results of HDM. Results Subjects were dominated by female (74%), 72% showed positive SPT results on HDM allergens. There were significantly different results between 2 groups: atopic history (p=0.000) (consists of allergic rhinitis (p= 0.004) and AD (p=0.029)); precipitating factor (p=0.042) (consists of food (p=0.045), and HDM (p=0.021)); positive SPT results of shrimp (p=0.030) and cow’s milk (p=0.047); chronically-relapsing dermatitis (p=0.016); immediate skin test reactivity (p=0.000); and raised serum IgE (p=0.018). There was no significant difference of AD signs and symptoms between the groups. The clinical relevance of the HDM allergy history from anamnesis and results of the HDM SPT was 60.0%. Conclusion Atopic dermatitis caused by HDM in Surabaya is common. There were several characteristics of AD patients with positive SPT to HDM. Clinical relevance showed that allergen recognizing is still challenging.References
Ardern-Jones MR, Flohr C, Reynolds NJ, Holden CA. Atopic Eczema. In: Griffiths CEM, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Rook’s Textbook of Dermatology. WILEY Blackwell; 2016. p. 41.1-41.34.
Simpson EL, Leung DYM, Eichenfield LF, Boguniewicz M. Atopic Dermatitis. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, et al., editors. Fitzpatrick’s Dermatology. New York: McGraw-Hill Education; 2019. p. 363–84.
Bumbacea RS, Corcea SL, Ali S, Dinica LC, Fanfaret IS, Boda D. Mite allergy and atopic dermatitis: Is there a clear link? (Review). Exp Ther Med. 2020;3554–60.
Wichmann K, Heratizadeh A, Werfel T. In-vitro diagnostic in atopic dermatitis: Options and limitations. Allergol Select. 2017;1(2): 150–9.
Tham EH, Lee AJ, van Bever H. Aeroallergen sensitization and allergic disease phenotypes in Asia. Asian Pac J Allergy Immunol. 2016;34(3):181–9.
Nugroho WT, Ervianti E, Zulkarnain I, Nurul Hidayati A, Damayanti, Utomo B, et al. Characteristics of Atopic Dermatitis Patients who Underwent Skin Prick Test. Berkala Ilmu Kesehatan Kulit dan Kelamin. 2022;34(1):11–4.
Nopriyati N, Antonius CS, Thaha HMA, Diba S, Kurniawati Y, Argentina F. Skin Prick Test Profile: A Retrospective Study. Berkala Ilmu Kesehatan Kulit dan Kelamin. 2022;34(3):189–96.
Huang FL, Liao EC, Yu SJ. House dust mite allergy: Its innate immune response and immunotherapy. Immunobiology. 2018;223(3):300–2.
Anggraeni S, Umborowati MA, Damayanti, Endaryanto A, Prakoeswa CRS. Correlation between Skin Prick Test and Specific IgE of Local Mites Allergen in Atopic Dermatitis Patients: an Indonesian Study. Chiang Mai University J Nat Sci. 2022;21(4):e2022053.
Sendrasoa FA, Ramily SL, Razafimaharo TI, Ranaivo IM, Andrianarison M, Raharolahy O, et al. Atopic dermatitis in adults: A cross-sectional study in the department of dermatology, Antananarivo, Madagascar. JAAD Int. 2021;4:28–31.
Kanda N, Hoashi T, Saeki H. The roles of sex hormones in the course of atopic dermatitis. Int J Mol Sci. 2019;20(19):4660. doi: 10.3390/ijms20194660.
Lee HH, Patel KR, Singam V, Rastogi S, Silverberg JI. A systematic review and meta-analysis of the prevalence and phenotype of adult-onset atopic dermatitis. J Am Acad Dermatol. 2019;80(6):1526–32.
Oninla OA, Akinkugbe AO, Otike-Odibi BI, Oripelaye MM, Olanrewaju FO. Atopic Dermatitis in Adults: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, and Management. In: Pereira C, editor. Atopic Dermatitis-Essential Issues. London: Intech Open; 2021.
Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. The Lancet. 2020; 396(10247):345–60.
Kulthanan K, Chularojanamontri L, Manapajon A, Nuchkull P. Prevalence and clinical characteristics of adult-onset atopic dermatitis with positive skin prick testing to mites. Asian Pac J Allergy Immunol. 2011; 29(4):318–26.
Ammar AM, Elham EA, Khayyal AES, Hamdy DM, EL-Gendy A, Elleboudy NAF. Role of interleukins 12B and 17A genetic variation in house dust mites allergy. Egypt J Med Hum Genet. 2020;21,60). https://doi.org/10.1186/s43042-020-00098-w
Sánchez-Borges M, Fernandez-Caldas E, Thomas WR, Chapman MD, Lee BW, Caraballo L, et al. International consensus (ICON) on: Clinical consequences of mite hypersensitivity, a global problem. World Allerg Org J 2017;10(1):1–26.
Emran H, Chieng CSE, Taib S, Cunningham AC. House dust mite sensitisation and association with atopic dermatitis in Brunei. Clin Transl Allergy. 2019;9(1):1–4.
Garna DR, Lucianus J, Ivone J. Descriptive Study on Skin Prick Test in Allergy Clinic Immanuel Hospital Bandung Indonesia. J Med Health. 2017;1(6):558–67.
Anggraeni S, Umborowati MA, Damayanti, Endaryanto A, Prakoeswa CRS. The Accuracy of Indonesian New Local Skin Prick Test (SPT) Allergen Extracts as Diagnostic Tool of IgE-mediated Atopic Dermatitis. Indian J Forensic Med Toxicol 2021;15(3):4278–85.
Holm JG, Agner T, Clausen M-L, Thomsen SF. Determinants of disease severity among patients with atopic dermatitis: association with components of the atopic march. Arch Dermatol Res. 2019;311(3):173–82.
Kulthanan K, Boochangkool K, Tuchinda P, Chularojanamontri L. Clinical features of the extrinsic and intrinsic types of adult-onset atopic dermatitis. Asia Pac Allergy. 2011;1(2):80–6.
Ott H, Stanzel S, Ocklenburg C, Merk H, Baron J, Lehmann S. Total Serum IgE as a Parameter to Differentiate Between Intrinsic and Extrinsic Atopic Dermatitis in Children. Acta Dermato Venereologica. 2009;89(3): 257–61.
