Histopathological analysis of skin biopsies in a tertiary care setting

Authors

  • Faiza Azam
  • Sidra Munir
  • Ameena Ashraf
  • Ambereen Anwar Imran
  • Tariq Rashid

Keywords:

Skin biopsy, papulosquamous disorders, eczema-dermatitis, blistering disorders, neoplastic lesions

Abstract

Objective To determine the spectrum and frequency of skin diseases on the basis of histopathology. Methods 152 skin biopsy specimens were received during a period of one year. They were processed routinely and findings recorded. Relevant demographic data as well as clinical findings were also noted. After diagnosis, the cases were divided into seven groups, viz, eczema-dermatitis, papulosquamous disorders, infectious disorders, blistering disorders, neoplastic lesions, degenerative diseases and miscellaneous lesions. Results were analyzed using percentage frequencies, Fischer’s exact test and student’s t test as appropriate. Results The age range of patients was 5-81 years with mean being 37.59±17 years. Majority of biopsies were from male patients (55.3%). Papulosquamous disorders were the most common group with a frequency of 46.7%. Second most frequent skin disease groups were eczema -dermatitis and blistering disorders, each accounting for 12.5 % of all biopsies. Neoplastic lesions constituted 10.5% of the lesions, with benign and malignant lesions presenting at the average ages of 47 and 43 years respectively. Conclusion The average age at presentation was close to that reported by other researchers from this region. The greater number of male patients is at variance from most other reported studies. The difference was statistically highly significant (p=0.0031). The frequency of different diagnostic groups was unique in some respects and conformed to other studies in others. The most striking was the statistically significant difference in age of presentation of patients with malignant neoplasms. This highlights the need to raise awareness in public about the possible precautionary measures that need to be taken, in this region with high levels of exposure to sunlight. 

References

Karimkhani C, Dellavalle RP, Coffeng LE, Flohr C, Hay RJ, Langan SM et al. Global skin disease morbidity and mortality: an update from the global burden of disease study 2013. JAMA Dermatol. 2017;153:406-12. doi: 10.1001/jamadermatol.2016.5538.

Dalgard F, Svensson A, Holm J0, Sundby J. Self-reported skin morbidity among adults: associations with quality of life and general health in a Norwegian survey. J Investig Dermatol Symp Proc. 2004;9:120-5.

Bangash E, Iqbal T, Iqbal S. Frequency of skin diseases presenting to a Primary Health Care Center in rural Islamabad, Pakistan. Rawal Med J. 2014;39:403-5.

Din T, Butt AQ, Bangash FA, Abbas H. Burden of skin diseases at a tertiary care hospital. J Rawal Med Coll. 2010;14:90-2.

Eisner P. Skin protection in the prevention of skin diseases. Curr Probl Dermatol. 2007;34:1-10.

Diepgen TL. Occupational skin diseases. J Dtsch Dermatol Ges. 2012;10:297-313. doi: 10.111 l/j.l610-0387.2012.07890.

Cahill J, Sinclair R. Cutaneous manifestations of systemic disease. Aust Fam Physician. 2005;34:335-40.

Aslan C, Gotkay F, Mansur AT, Aydingoz IE, Gunes P, Ekmekci TR. Clinicopathological consistency in skin disorders: A retrospective study of 3949 pathological reports. J Am Acad Dermatol. 2012;66:393-400. doi: http://dx.doi.org/ 10.1016/jjaad.2010.12.0319.

Shrestha P, Mikrani JA. Pattern of dermatological disease and its relation to gender in Lumbini Medical College Teaching Hospital. J Lumbini Med Coll. 2015;3:16-8. doi: 10.22502/jlmc.v3il.63.

Kumar A, Shrestha PR, Pun J, Thapa P, Manandhar M, Sathian B. Profile of skin biopsies and pattern of skin cancer in a tertiary care center of Western Nepal. Asian Pac J Cancer Prev. 2015;16:3403-6.

Kayhan M, Unluoglu I, Kayhan S, Bilge U. Assesment of clinical diagnosis, age and gender differences of elderly patients applying to dermatology clinic of a secondary health institute in family medicine aspect. Biomed Res. 2017;28:630-3.

Goltz RW. Dermatitis, papulosquamous disorders and psoriasis. Pathology. 1981;13:389.

Abdel-Hafez K, Abdel-Aty MA, Hofny ERM. Prevalence of skin diseases in rural areas of Assiut Governorate, Upper Egypt. Int J Dermatol. 2003;42:887-92.

Ananthaswamy HN. Sunlight and skin cancer. J Biomed Biotechnol. 2001;1:49. doi: 10.1155/S1110724301000122

Humayun Q, Iqbal R, Azam I, Khan AH, Siddiqui AR, Ansari NB. Development and validation of sunlight exposure measurement questionnaire (SEM-Q) for use in adult population residing in Pakistan. BMC Public Health 2012;12:421. https://doi.org/ 10.1186/ 1471-2458-12-421.

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Published

2018-07-11

How to Cite

1.
Azam F, Munir S, Ashraf A, Imran AA, Rashid T. Histopathological analysis of skin biopsies in a tertiary care setting. J Pak Assoc Dermatol [Internet]. 2018Jul.11 [cited 2025Feb.9];27(2):154-7. Available from: http://www.jpad.com.pk/index.php/jpad/article/view/1083

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