Necrolytic acral erythema without hepatitis and hypozincemia: A rare presentation.

Authors

  • Tasleem Arif Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, India
  • Dinesh Raj Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, India
  • Syed Suhail Amin Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, India

DOI:

https://doi.org/10.66344/jpad.v27i4.986

Keywords:

Hepatitis C, hypoaminoacidemia, necrolytic acral erythema, zinc deficiency

Abstract

Necrolytic acral erythema (NAE) is a recently described entity from Egypt by El Darouti and Abu el Ela in seven patients with associated hepatitis C virus infection. It is characterized by its distinguishing psoriasiform skin lesions, an acral distribution, and histological features. The cause of the disease is not clear, though zinc deficiency, hypoaminoacidemia and hyperglucagonemia have been proposed. There are few reports in which it has occurred independently without associated HCV infection. However, NAE without associated HCV infection and normal serum zinc levels has been rarely reported till date. Herein, the authors report a rare case of NAE from India without associated HCV infection and with a normal serum zinc concentration.

Author Biography

  • Tasleem Arif, Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, India

    Dr. Tasleem Arif.

    MBBS, MD (Dermatology, STD & Leprosy).

    Assistant Professor, Postgraduate Department of Dermatology, STDs and Leprosy.

    Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University, Aligarh, India.

    Address for correspondence: Al-Rahman Apartment, ground floor, Behind Zakaria market, New Sir Syed Nagar, Civil lines Aligarh, India.

    Cell number: +919557480345.

    Permanent Address: New colony Soura, near water supply control room, Srinagar, Kashmir, India.

    PIN: 190011

    Email: dr_tasleem_arif@yahoo.com

References

1. El Darouti M, Abu el Ela M. Necrolytic acral erythema: A cutaneous marker of viral hepatitis C. Int J Dermatol. 1996;35:252-6.

2. Patel U, Loyd A, Patel R, Meehan S, Kundu R. Necrolytic acral erythema. Dermatol Online J. 2010;16:15.

3. Nofal AA, Nofal E, Attwa E, El-Assar O, Assaf M. Necrolytic acral erythema: A variant of necrolytic migratory erythema or a distinct entity? Int J Dermatol. 2005;44:916-21.

4. Abdallah MA, Hull C, Horn TD. Necrolytic acral erythema: A patient from the United States successfully treated with oral zinc. Arch Dermatol. 2005;141:85-7.

5. Abdallah MA, Ghozzi MY, Monib HA, Hafez AM, Hiatt KM, Smoller BR et al. Necrolytic acral erythema: A cutaneous sign of hepatitis C virus infection. J Am Acad Dermatol. 2005;53:247-51.

6. Wu YH, Tu ME, Lee CS, Lin YC. Necrolytic acral erythema without hepatitis C infection. J Cutan Pathol. 2009;36:355-8.

7. Bentley D, Andea A, Holzer A, Elewski B. Lack of classic histology should not prevent diagnosis of necrolytic acral erythema. J Am Acad Dermatol. 2009;60:504–7.

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Published

27.05.2018

How to Cite

1.
Necrolytic acral erythema without hepatitis and hypozincemia: A rare presentation. J Pak Assoc Dermatol [Internet]. 2018 May 27 [cited 2026 Aug. 1];27(4):401-4. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/986