Werner syndrome: A case report and review of literature
Keywords:
Pangeria, Werner syndrome, progeria adultorumAbstract
Werner’s syndrome is a rare inherited disorder characterized by short stature, sclerosed skin, cataract and premature aging of the face. The disease involves multiple systems of the body and some of the abnormalities may cause life threatening complications such as myocardial infarction and malignancy. We report a case of this rare disorder.References
Burrow NP, Lovell CR. Disorders of connective tissue. In: : Burns T, Breathnach S, Cox N, Griffiths C, eds. Rook’s Textbook of Dermatology, 7th edn. London: Blackwell Science; 2004. P. 46.57-58.
Runger TM, Digiovanna JJ, Kraemer KH. Hereditary disorders of genome instability and DNA repair. In: Fitzpatrick’s Dermatology in General Medicine, 7th edn. USA: McGraw-Hill; 2008. P. 1323-1330.
Sert M, Fakioglu K, Tetiker T. Review of two siblings with Werner's syndrome. Case Report Med 2009: 2009; 1383-12
Yamamoto K, Imakiire A, Miyagawa N, Kasahara T. A report of two cases of Werner's syndrome and review of the literature. Orthop Surg 2003; 11: 224-33.
Yamanaka A, Hirai T, Ohtake Y et al. Lung cancer associated with Werner’s syndrome. Clin Oncol 1997; 27: 415-8.
Janniger CK, Wozniacka A. Werner syndrome. (online) 2010 available from http://www.emed.com /derm . Updated: Jun 25, 2010.
Oshima J, EnYu C, Piussan C, Jabkowski J. Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum Mol Genet 1996; 5: 1909-3.
Best BP. Nuclear DNA damage as a direct cause of aging. Rejuvenation Research 2009; 12 (online). Available from: http://www.ncbi.nlm.nih.gov/pubmed/19594328
Ahn B, Bohr VA. DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease. Biochem Biophys Res Commun 2011; 411: 684-9.
Nair SP, Vijayadharan M, Gupta A. Werner's syndrome. Indian J Dermatol Venereol Leprol 1998; 64: 31-3.
Tannock TC, Cook RF. A case of a delusional psychotic syndrome in the setting of Werner syndrome. Br J Psych 1988; 152: 703-70.
Tao LC, Stecker E, Gardner HA. Werner syndrome and acute myeloid leukemia. Can Med Assoc J 1971; 105: 951.
Soto-Figueroa SF, Nussbaum R L, Garcia E. A case of myocardial infarction in a patient with Werner syndrome. Texas Heart Institute J 1984; 11: 80-3.
Tsuji Y, Kusuzaki K, Kanemitsu K et al. Calcaneal osteosarcoma associated with Werner syndrome. J Bone Joint Surg 2000; 82:1308-13.
Acharya KM, Mukhopadhyay A, Agarwal S. Pangeria. Indian J Dermatol Venereol Leporol 1995; 61: 229-30.
Robinson K, Asawachaicharn N, GallowayD A, Grandori C. c-Myc accelerates S-phase and requires WRN to avoid replication stress. PLoS One 2009; 4: e5951.