An unusual case of dapsone syndrome with a prolonged remitting and relapsing course lasting eight months: a case report
Keywords:
Dapsone hypersensitivity syndrome, granulomatous hepatitis, exfoliative dermatitis, leprosy, dapsoneAbstract
Dapsone hypersensitivity syndrome is a well established entity which has been reported in literature since the 1950's. A unique case of dapsone syndrome which had a very prolonged course of eight months is reported with no similar precedence in literature. With the wide use of dapsone in many medical conditions, clinicians should be aware that dapsone can cause a prolonged clinical syndrome of dapsone hypersensitivity which might mimic other sinister conditions.ÂReferences
Yawalkar SJ, McDougall AC, Languillon J et al. Once-monthly rifampicin plus daily dapsone in initial treatment of lepromatous leprosy. Lancet 1982; 1: 1199-1202.
Wozel VE. Innovative use of dapsone. Dermatol Clin 2010; 28: 599-610.
Agrawal S, Agarwalla A. Dapsone hypersensitivity syndrome: a clinico-epidemiological review. J Dermatol 2005; 32: 883-9.
Millikan LE, Harrell ER. Drug reactions to the sulfones. Arch Dermatol 1970; 102: 220-4.
DeGowin RL. A review of therapeutic and hemolytic effects of dapsone. Arch Intern Med 1967; 120: 242-8.
Johnson DA, Cattau EL Jr, Kuritsky JN, Zimmerman HJ. Liver involvement in the sulfone syndrome. Arch Intern Med 1986; 146: 875-7.
Lons T, Richardet JP, Machayekhi JP et al. Granulomatous hepatitis caused by dapsone. Gastroenterol Clin Biol 1992; 16: 293.
Zhu YI, Stiller MJ. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol 2001; 45: 420-34.
Zimmerman HJ, Lewis JH. Chemical and toxin-induced hepatotoxicity. Gastroenterol Clin North Am 1995; 24: 1027-45.
Kosseifi SG, Guha B, Nassour DN et al. The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations. J Occup Med Toxicol 2006; 1: 9.
