Cutaneous metastasis as presenting feature of internal malignancy - report of two cases
DOI:
https://doi.org/10.66344/jpad.v20i4.383Keywords:
Cutaneous metastasis, internal malignancyAbstract
Cutaneous metastasis (CM) from internal malignancy is usually seen in advanced stage and hence is associated with bad prognosis. Sometimes, CM alone is a presenting feature without any obvious feature of internal malignancy. High index of suspicion and histopathology can establish the diagnosis of CM. Identification of underlying malignancy is based on clinical futures, histopathology, immunohistochemistry and other investigations. CM was the presenting feature in our cases and identification of CM led to search for underlying malignancy and then initiation of therapy.
References
1. Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: a meta-analysis of data. South Med J 2003; 96: 164-7
2. Wollina U, Graefe T, Konrad H et al. Cutaneous metastases of internal cancer. Acta Derma Venereol APA 2004; 13: 79-84. Available from: http://ibmi.mf.uni-lj.si/acta-apa/acta-apa-04-3/acta-apa-04-3.html
3. Lookingbill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma. A retrospective study of 7316 cancer patients. J Am Acad Dermatol 1990; 22: 19-26.
4. Davis D, Pellowsky D. Cutaneous metastases. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology, 2nd edn. Philadelphia: Mosby Elsevier; 2008. P. 1953-8
5. Debois JM. Metastases to the skin, soft tissue and bone. In: Debois JM. TxNxM1 The Anatomy and Clinics of Metastatic Cancer. 1st ed. Oxford: Springer; 2002. P. 209-15.
6. Federman DG, Kravetz JD, Kirsner RS, Heald WS. Cutaneous metastases. In: Nouri K, ed. Skin cancer. 1st edn. McGraw-Hill;. 2008. P. 380-5
7. Saeed S, Keehn CA, Morgan MB. Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal. J Cutan Pathol 2004; 31: 419-30.
8. Garg PK, Khurana N, Hadke NS. Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma. Hepatobiliary Pancreat Dis Int 2009; 8: 209-11.
9. Kaur J, Puri T, Julka PK et al. Adenocarcinoma of the gall bladder presenting with a cutaneous metastasis. Indian J Dermatol Venereol Leprol 2006; 72: 64-6.
10. Gandotra G, Gupta B, Kapoor R, Gupta A. Cutaneous metastasis: A rare clinical entity. http://www.jkscience.org/list_articles.php?volume=1&issueno=4
11. Debois JM. Metastases from cancers of the abdominal organs. In: Debois JM. TxNxM1 The Anatomy and Clinics of Metastatic Cancer. 1st ed. Philadelphia: Springer; 2002. P. 425-9
12. Pandey M, Aryya NC, Pradhan S et al. Carcinoma of the gallbladder presenting as scalp tumour. Eur J Surg Oncol 1998; 24: 605-7.
13. Brownstein MH, Helwig EB. Spread of tumours to the skin. Arch Dermatol 1973; 107: 80-6
14. Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: A retrospective study of 4020 patients. J Am Acad Dermatol 1993; 29: 228-36.
15. Horvath LZ, Flautner LE, Tihanyi TF, Miklos IJ. Trocar site metastasis of gall bladder cancer after laparoscopic cholecystectomy. Minimally Invas Ther Allied Technol 1996; 5, 193-6.
16. Rueben S, Owen D, Lee P, Weiss A. Hepatocellular carcinoma with cutaneous metastases. Can J Gastroenterol 2009; 23: 23-5.
17. Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995; 33: 161-82.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 Piyush Kumar, Avijit Mondal, Tanusree Sarkar, R C Gharami, Nilay Kanti Das, Satyendra Nath Chowdhury, Arunasis Maiti
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
