Correlation between Serum Heat Shock Protein–27 (HSP–27) Levels with Facial Skin Aging
DOI:
https://doi.org/10.66344/jpad.v36i3.3494Keywords:
HSP–27 serum, facial skin aging, intrinsic, extrinsicAbstract
Background Facial skin aging is influenced by intrinsic and extrinsic factors, particularly ultraviolet (UV) radiation, which increases oxidative stress and cellular damage. Heat Shock Protein-27 (HSP-27) helps protect cells from oxidative damage. However, studies examining the relationship between serum HSP-27 levels and facial skin aging remain limited in this population.
Objective This study aimed to analyze the relationship between serum HSP-27 levels and facial skin aging.
Methods Eighty subjects were included, consisting of 40 subjects aged 20-40 years with facial skin aging and 40 control subjects aged 18-25 years without signs of facial skin aging. Subjects were selected using consecutive sampling. Facial skin aging was assessed using the Dermoscopic Photoaging Scale (DPAS), while serum HSP-27 levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA).
Results Mean serum HSP-27 levels were lower in the facial skin aging group than in the control group (17.26±2.79 ng/mL vs. 52.72±24.50 ng/mL). The Mann-Whitney test showed a significant difference between groups (P<.001).
Conclusion Serum HSP-27 levels were significantly associated with facial skin aging, with lower levels observed in subjects with facial skin aging. HSP-27 may serve as a supporting biomarker and warrants further investigation with larger samples and robust study designs.
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