Clinical Efficacy of the ProYellow Laser for the Treatment of Steroid-Induced Facial Dermatosis in Premenopausal Iraqi Women: A Quasi-experimental study
DOI:
https://doi.org/10.66344/jpad.v36i3.3450Keywords:
Laser Therapy, Face, GlucocorticoidsAbstract
Background Topical corticosteroids are widely used in dermatology for their potent anti-inflammatory and immunosuppressive properties. Nevertheless, inappropriate use of or prolonged treatment with topical corticosteroids in facial skin can result in a characteristic clinical presentation called steroid-induced facial dermatitis.
Objective To compare ProYellow laser therapy to traditional treatment in Iraqi patients with steroid-induced facial dermatitis, focusing on severity of erythema and pigmentationand patient satisfaction.
Methods Eligible premenopausal women with steroid-induced facial dermatitis unresponsive to previous topical therapy were enrolled. Participants received either three monthly sessions of 577-nm QuadroStar® PRO Yellow laser or conventional topical treatment for three months. Facial erythema and pigmentation were assessed using standardized 0-4 scales, and patient satisfaction was compared between the groups
Results Total number of patients included were 101 (laser group, n=50; conventional treatment, n=51). After treatment, there was no erythema in 48.0% vs. 0% of the laser group and conventional-treatment group, respectively, and severe erythema persisted in 0% vs. 43.1%, respectively (P<0.001). Patient satisfaction was significantly higher in the laser group (95.8% vs. 2.0%; P<0.001). No adverse events related to the treatment were noted.
Conclusion Compared to usual treatment, ProYellow laser therapy reduced facial erythema and pigmentation in steroid induced facial erythema significantly. Laser patients had faster clinical improvement, shorter treatment duration, and more patient satisfaction.
References
1. Shaheen S, Shahbaz A, Maqbool N, Shaheen JA. Use of topical corticosteroids and mixed creams over the face among female medical students of Quaid-e-Azam Medical College, Bahawalpur. J Pak Assoc Dermatol. 2020;30(1):143-50. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1514.
2. Teo WY, Lim YYE, Sio YY, Say YH, Reginald K, Chew FT. Atopic dermatitis-associated genetic variants regulate LOC100294145 expression implicating interleukin-27 production and type 1 interferon signaling. World Allergy Organ J. 2024;17(2):100869. doi: 10.1016/j.waojou.2023.100869.
3. Tan SY, Chandran NS, Choi EC. Steroid Phobia: Is There a Basis? A Review of Topical Steroid Safety, Addiction and Withdrawal. Clin Drug Investig. 2021;41(10):835-42. doi: 10.1007/s40261-021-01072-z.
4. Jain S, Mohapatra L, Mohanty P, Jena S, Behera B. Study of Clinical Profile of Patients Presenting with Topical Steroid-Induced Facial Dermatosis to a Tertiary Care Hospital. Indian Dermatol Online J. 2020;11(2):208-11. doi: 10.4103/idoj.IDOJ_259_19.
5. Silverberg JI, de Bruin-Weller M, Bieber T, Soong W, Kabashima K, Costanzo A, Rosmarin D, Lynde C, Liu J, Gamelli A, Zeng J, Ladizinski B, Chu AD, Reich K. Upadacitinib plus topical corticosteroids in atopic dermatitis: Week 52 AD Up study results. J Allergy Clin Immunol. 2022;149(3):977-87.e14. doi: 10.1016/j.jaci.2021.07.036.
6. Chudal D, Paudel V. Misuse of Topical Corticosteroids in Dermatological Disorders in Tribhuvan University Teaching Hospital. J Nepal Health Res Counc. 2021;18(4):729-33. doi: 10.33314/jnhrc.v18i4.2832.
7. Hasan EF, Ahmed MH, Hraiga NM. Evaluating the Clinical Outcomes of Using Pro-Yellow Laser for Steroid-Induced Rosacea: A Prospective Clinical Study. Al-Rafidain J Med Sci. 2025;9(2):327-32. Available from: https://ajms.iq/index.php/ALRAFIDAIN/article/view/2445
8. Fan X, Yin Y, Dou W, Li T, Xue P, Yang Q, Ma Q. Successful Treatment of Corticosteroid-Induced Rosacea-Like Dermatitis with Platelet-Rich Plasma Mesotherapy: Report of Seven Cases. Dermatol Ther (Heidelb). 2021;11(2):615-23. doi: 10.1007/s13555-021-00492-1.
9. Hrițcu OMC, Costan V-V, Toader ȘV, Brănișteanu DE, Toader MP. From Lasers to Longevity: Exploring Energy-Based Devices as Senotherapeutic Tools in Dermatology. Cosmetics. 2025; 12(5):201. https://doi.org/10.3390/cosmetics12050201
10. Mohamed EM, Abd Elaleem HL, Ahmed MAH, Rageh MA. Efficacy and Safety of 577-nm Yellow Laser in the Treatment of Pigmented Epidermal Lesions. Lasers Surg Med. 2024;56(6):551-6. doi: 10.1002/lsm.23814.
11. Seo JK, Shin EJ, Jeong KH, Shin MK. Clinician Severity Assessment Grading Scale on Erythematotelangiectatic Rosacea. Indian J Dermatol. 2021;66(2):203-5.
doi: 10.4103/ijd.IJD_611_19.
12. Kesty CE, Kesty KR. The Kesty Hyperpigmentation Scale: A Study to Validate a New Tool for Assessing Facial Hyperpigmentation. J Cosmet Dermatol. 2025;24(4):e70055. doi: 10.1111/jocd.70055.
13. Zhai Q, Cheng S, Liu R, Xie J, Han X, Yu Z. Meta-Analysis of the Efficacy of Intense Pulsed Light and Pulsed-Dye Laser Therapy in the Management of Rosacea. J Cosmet Dermatol. 2024;23(12):3821-7. doi: 10.1111/jocd.16549.
14. Asclepion Laser Technologies GmbH. QuadroStar® PRO Yellow laser system: technical specifications. Jena, Germany; 2018.
15. Woo SS, Gwak H, Han SS, Suh IS, Kim SH. Evaluation of the Pinhole Method Using Carbon Dioxide Laser on Facial Telangiectasia. J Clin Med. 2023;12(8):2849.
doi: 10.3390/jcm12082849.
16. Deaver Peterson J, Katz TM. Open-label study assessing the efficacy and tolerability of topical skin care and sun protection alone and in combination with intense pulsed light therapy. J Cosmet Dermatol. 2019;18(6):1758-64. doi: 10.1111/jocd.12952.
17. Cai Y, Zhu Y, Xiang W, Song X. Efficacy and safety of intense pulsed light for the treatment of facial erythema: a systematic review and meta-analysis. Ital J Dermatol Venerol. 2023;158(3):236-42. doi: 10.23736/S2784-8671.23.07499-6.
18. Zhang AD, Clovie J, Lazar M, Vashi NA. Treatment of Benign Pigmented Lesions Using Lasers: A Scoping Review. J Clin Med. 2025;14(11):3985. doi: 10.3390/jcm14113985.
19. Yepuri V, Patil AD, Fritz K, Salavastru C, Kroumpouzos G, Nisticò SP, Piccolo D, Sadek A, Badawi A, Kassir M, Gold MH, Große-Büning S, Grabbe S, Goldust M. Light-Based Devices for the Treatment of Facial Erythema and Telangiectasia. Dermatol Ther (Heidelb). 2021;11(6):1879-87. doi: 10.1007/s13555-021-00607-8.
20. Bae YC, Rettig S, Weiss E, Bernstein L, Geronemus R. Treatment of Post-Inflammatory Hyperpigmentation in Patients With Darker Skin Types Using a Low Energy 1,927 nm Non-Ablative Fractional Laser: A Retrospective Photographic Review Analysis. Lasers Surg Med. 2020;52(1):7-12. doi: 10.1002/lsm.23173.
21. Yoshida A, Sugita K, Yamamoto O. Infiltrative Erythemas and Nodules on a Unilateral Cheek Following Inappropriate Use of a Topical Steroid. Yonago Acta Med. 2022;65(1):88-9. doi: 10.33160/yam.2022.02.003.
22. Alexiades M. Laser and light-based treatments of acne and acne scarring. Clin Dermatol. 2017;35(2):183-9. doi: 10.1016/j.clindermatol.2016.10.012.
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