Autologous noncultured epidermal cell suspension in case of resistant segmental vitiligo: a preliminary study

Authors

  • Iffat Hassan Postgraduate Department of Dermatology, STD & Leprosy, Govt. Medical College, Srinagar
  • Syed Mubashir Postgraduate Department of Dermatology, STD & Leprosy, Govt. Medical College, Srinagar
  • Zubair Abdullah Postgraduate Department of Dermatology, STD & Leprosy, Govt. Medical College, Srinagar
  • Peerzada Sajad Postgraduate Department of Dermatology, STD & Leprosy, Govt. Medical College, Srinagar
  • Parvaiz Anwar Postgraduate Department of Dermatology, STD & Leprosy, Govt. Medical College, Srinagar
  • Gousia Sheikh Postgraduate Department of Dermatology, STD & Leprosy, Govt. Medical College, Srinagar
  • Abdul Sami Postgraduate Department of Dermatology, STD & Leprosy, Govt. Medical College, Srinagar
  • Atiya Yaseen Postgraduate Department of Dermatology, STD & Leprosy, Govt. Medical College, Srinagar

DOI:

https://doi.org/10.66344/jpad.v23i2.306

Keywords:

Vitiligo, autologous, noncultured epidermal cell suspension, melanocytes, trypsinization

Abstract

Objective To assess the repigmentation efficacy of noncultured epidermal cell suspension (NCECS) in case of resistant segmental vitiligo.

 

Patients and methods Three patients having resistant segmental vitiligo were treated with noncultured epidermal cell suspension at the Department of Dermatology, STD & Leprosy, SMHS Hospital (associated teaching hospital of Govt. Medical College, Srinagar) and were followed up for six months.

 

Results Two patients showed more than 70% response, one patient more than 50% response. The pattern of pigmentation was uniform and aesthetically acceptable.

 

Conclusion Autologous non cultured epidermal cell suspension is one of the best modalities as far as segmental vitiliginous patches resistant to other treatment  modalities are concerned and is one of the novel techniques as far as its outcome is concerned in the form of uniform pigmentation.

References

1. Sehgal VN, Srivastava G. Vitiligo compendium of clinicoepidemiological features. Indian J Dermatol Venereol Leprol. 2007;73:149-56.

2. Savant SS. Surgical therapy of vitiligo: current status. Indian J Dermatol Venereal Leprol. 2005;71:307-10.

3. Parsad D, Gupta S. Standard guidelines of care for vitiligo surgery. Indian J Dermatol Venereol Leprol. 2008;74:37-45.

4. Mulekar SV. Melanocyte-keratinocyte cell transplantation for stable vitiligo. Int J Dermatol. 2003;42:132-6.

5. Mulekar SV. Long-term follow-up study of segmental and focal vitiligo treated by autologous, non-cultured melanocyte-keratinocyte cell transplantation. Arch Dermatol. 2004;140:1211-5.

6. Mulekar SV, Al Eisa A, Delvi MB et al. Childhood vitiligo: A long term study of localized vitiligo treated by non-cultured cellular grafting. Pediatr Dermatol. 2010;27:132-6.

7. Olsson MJ, Juhlin L. Long term follow-up study of leucoderma patients treated with transplants of autologous cultured melanocytes, ultrathin epidermal sheets and basal cell layer suspension. Br J Dermatol. 2002;147:893-904.

8. Van Geel N, Ongenae K, Vander Haeghen Y et al. Subjective and objective evaluation of non-cultured epidermal cellular grafting for repigmenting vitiligo. Dermatology. 2006;213:23-9.

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Published

15.12.2016

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Original Articles

How to Cite

1.
Autologous noncultured epidermal cell suspension in case of resistant segmental vitiligo: a preliminary study. J Pak Assoc Dermatol [Internet]. 2016 Dec. 15 [cited 2026 Jul. 28];23(2):190-3. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/306