A rare case of multiple keratoacanthomas of Grzybowski
Keywords:
Keratoacanthomas, Ectropion, Hair folliclesAbstract
Generalized eruptive keratoacanthoma (GEKA) of Grzybowski is a rare variant of keratoacanthoma with an unclear pathophysiology. GEKA originates from the hair follicle with a keratotic center and shows histological features of keratoacanthoma. Herein, we report a case of a female 79 years of age with multiple pruritic eruptions over sun-exposed areas, including facial involvement with ectropion. GEKA represents a diagnostic and therapeutic challenge due to the lack of distinct clinical presentation and efficient treatment. ÂReferences
Jaber PW, Cooper PH, Greer KE. Generalized eruptive keratoacanthoma of Grzybowski. J Am Acad Dermatol. 1993;29(2 Pt 2):299-304.
doi: 10.1016/0190-9622(93)70180-2.
Anzalone CL, Cohen PR. Generalized eruptive keratoacanthomas of Grzybowski. Int J Dermatol. 2014;53(2):131-6.
doi: 10.1111/ijd.12318.
Liu LQ, Jiao T, Wang JY. Irreversible blindness in generalized eruptive keratoacanthoma of Grzybowski. Clin Exp Dermatol. 2021;46(7):1376-8.
doi: 10.1111/ced.14702.
Oakley A, Ng S. Grzybowski's generalized eruptive keratoacanthoma: remission with cyclophosphamide. Australas J Dermatol. 2005;46(2):118-23.
doi: 10.1111/j.1440-0960.2005.00157.x.
Schwartz RA, Błaszczyk M, Jablonska S. Generalized eruptive keratoacanthoma of Grzybowski: follow-up of the original description and 50-year retrospect. Dermatology. 2002;205(4):348-52.
doi: 10.1159/000066422.
Nofal A, Nofal E. Generalized eruptive keratoacanthoma of Grzybowski: strict diagnostic criteria are still lacking. Clin Exp Dermatol. 2014;39(1):87-8.
doi: 10.1111/ced.12178.
Rotola A, Musmeci D, Gentili V, Reale D, Borghi A, Rizzo R, Corazza M. Generalized eruptive keratoacanthoma of the Grzybowski type: some considerations on treatment and pathogenesis. Int J Dermatol. 2019;58(12):e242-e245.
doi: 10.1111/ijd.14548.
Nofal A, Assaf M, Ghonemy S, Nofal E, Yosef A. Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. Int J Dermatol. 2015;54(2):160-7.
doi: 10.1111/ijd.12308.
Havenith R, de Vos L, Fröhlich A, Braegelmann C, Sirokay J, Landsberg J, Wenzel J, Bieber T, Niebel D. Grzybowski's Generalized Eruptive Keratoacanthomas in a Patient with Terminal Kidney Disease-An Unmet Medical Need Equally Ameliorated by Topical Imiquimod Cream and Lapacho Tea Wraps: A Case Report. Dermatol Ther (Heidelb). 2021;11(2):625-38.
doi: 10.1007/s13555-021-00502-2.
Consigli JE, González ME, Morsino R, Guidi A, Chappuis JM, Papa M, Maldonado S. Generalized eruptive keratoacanthoma (Grzybowski variant). Br J Dermatol. 2000;142(4):800-3.
doi: 10.1046/j.1365-2133.2000.03430.x.
Abbas MN, Tan WS, Kichenadasse G. Sorafenib-related generalized eruptive keratoacanthomas (Grzybowski syndrome): a case report. J Med Case Rep. 2021;15(1):481.
doi: 10.1186/s13256-021-03037-4.
Street ML, White JW Jr, Gibson LE. Multiple keratoacanthomas treated with oral retinoids. J Am Acad Dermatol. 1990;23(5 Pt 1):862-6.
doi: 10.1016/0190-9622(90)70305-2.
Filippi F, Carpanese MA, Sacchelli L, Loi C, Chessa MA, Bardazzi F. Two birds with one stone: Successful treatment with methotrexate in a patient with generalized eruptive keratoacanthoma of Grzybowski and rheumatoid arthritis. Dermatol Ther. 2022;35(11):e15787.
doi: 10.1111/dth.15787.
Mascitti H, De Masson A, Brunet-Possenti F, Bouaziz JD, Laly P, Mourad N, Garrigues JM, Laurent-Roussel S, Cavelier-Balloy B, Moulonguet I, Leschi C, Mourah S, Bagot M, Lebbé C, Basset-Seguin N. Successful Treatment of Generalized Eruptive Keratoacanthoma of Grzybowski with Acitretin. Dermatol Ther (Heidelb). 2019;9(2):383-8.
doi: 10.1007/s13555-019-0287-0.
Nofal A, Assaf M, Nofal E, Alradi M. Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation. J Eur Acad Dermatol Venereol. 2014;28(4):397-404.
doi: 10.1111/jdv.12226.
Rath S, Cowan BJ, Dolman PJ. Cicatricial ectropion in grzybowski type of multiple eruptive keratoacanthomas. Ophthalmic Plast Reconstr Surg. 2014;30(2):e42-3.
doi: 10.1097/IOP.0b013e318295f946.
Haas N, Schadendorf D, Henz BM, Fuchs PG. Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus. Br J Dermatol. 2002;147(4):793-6.
doi: 10.1046/j.1365-2133.2002.04925.x.
Kavanagh GM, Marshman G, Hanna MM. A case of Grzybowski's generalized eruptive keratoacanthomas. Australas J Dermatol. 1995;36(2):83-5.
doi: 10.1111/j.1440-0960.1995.tb00938.x.