The interrelation between HIV and condyloma acuminata high-risk strain
HIV AND CONDYLOMA ACUMINATA
DOI:
https://doi.org/10.66344/jpad.v33i3.2264Keywords:
High-risk HPV strains, human papillomavirus, humhuman immunodeficiency virus, immunohistochemistryAbstract
Objective The purpose of this study is to determine the relationship of high-risk HPV (HR-HPV) strain with IHC staining between HIV and non-HIV patients.
Methods This study is cross-sectional research that involved 41 CA patients who underwent a biopsy to obtain histopathological data. A consecutive non-random sampling technique was used to select the subjects. The subjects were divided into CA with HIV and CA with non-HIV, we divide the subjects with ELISA examination. The IHC staining was subsequently performed to determine the HR-HPV strain. The finding was interpreted based on immunoreactive cells.
Results The average age of the HR-HPV strains group was 31.20±16.87 years, and the average age of its negative strains was 33.19±12.41 years (p=0.931). HIV-positive patients were 5 (100%) with HR-HPV, yet none was found in HIV-negative. Conversely, 12 patients (33.3%) are HIV-positive patients with low risk (LR)-HPV and 24 HIV-negative patients (66.7%) with LR-HPV. Statistic results showed a significant relationship between HIV incidence and HR-HPV (p=0.005). Patients with negative HR-HPV have a 0.810 times lower risk of HIV than positive HR-HPV.
Conclusion This study demonstrated that negative HR-HPV was a protective effect of HIV. CA patients with HIV infection were examined for high-risk CA strains with IHC staining to help determine prognosis and therapy.
References
1. Yanofsky VR, Patel R V, Goldenberg G. Genital warts: a comprehensive review. J Clin Aesthet Dermatol. 2012;5(6):25–36.
2. Sugai S, Nishijima K, Enomoto T. Management of Condyloma Acuminata in Pregnancy. Sex Transm Dis. 2021;48(6): 403-9.
3. Indriatmi W, Zubier F, Daili S, Nilasari H. Benign Lesions of Human Papillomavirus Infection in the Anogenital Region. In: Human Papillomavirus Infection. Jakarta: Publishing Agency of the Faculty of Medicine, University of Indonesia; 2013.
4. Mawardi P, Febrianto B, Yuliarto D, Sumandjar T. Comparing the Efficacy of Chemical Cautery to Cryosurgery on CD4+ Status of HIV Patients with Condyloma Acuminata. Clin Cosmet Invest Dermatol. 2021;14:1453.
5. Park E, Kim J-Y, Choi S, Kim DS, Oh YL. Carcinogenic risk of human papillomavirus (HPV) genotypes and potential effects of HPV vaccines in Korea. Sci Rep. 2019;9(1):12556.
6. Sundström K, Ploner A, Arnheim-Dahlström L, Eloranta S, Palmgren J, Adami H-O, et al. Interactions Between High- and Low-Risk HPV Types Reduce the Risk of Squamous Cervical Cancer. JNCI J Natl Cancer Inst. 2015;107(10):djv185.
7. Hawkins MG, Winder DM, Ball SL, Vaughan K, Sonnex C, Stanley MA, et al. Detection of specific HPV subtypes responsible for the pathogenesis of condylomata acuminata. Virol J. 2013;10(1):137.
8. Egelkrout E, Galloway D. The biology of genital human papillomaviruses. In: Holmes K, Sparling P, Stamm W, Piot P, Wasserheit J, Corey L, et al., editors. Sexually transmitted disease. 4th ed. New York, McGraw Hil: The McGraw-Hill Companies; 2008. p. 463–88.
9. Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report (Sexually Transmitted Diseases Treatment Guidelines). Georgia: U. S. Department of Health and Human Services; 2015.
10. Keshinro B, Crowell TA, Nowak RG, Adebajo S, Peel S, Gaydos CA, et al. High prevalence of HIV, chlamydia and gonorrhoea among men who have sex with men and transgender women attending trusted community centres in Abuja and Lagos, Nigeria. J Int AIDS Soc. 2016;19(1):21270.
11. Sung JH, Ahn EJ, Oh H-K, Park SH. Association of Immune Status with Recurrent Anal Condylomata in Human Immunodeficiency Virus-Positive Patients. J Korean Soc Coloproctol. 2012;28(6):294.
12. Williamson A-L. The Interaction between Human Immunodeficiency Virus and Human Papillomaviruses in Heterosexuals in Africa. J Clin Med. 2015;4(4):579–92.
13. Wititsuwannakul J, Klump VR, McNiff JM, Ko CJ. Detecting HPV in Cutaneous Lesions Using Anti-HPV Antibody Immunohistochemistry. Am J Dermatopathol. 2013;35(3):327–31.
14. Tomaić V. Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites. Cancers (Basel). 2016;8(10):95.
15. Ehehalt D, Lener B, Pircher H, Dreier K, Pfister H, Kaufmann AM, et al. Detection of Human Papillomavirus Type 18 E7 Oncoprotein in Cervical Smears : a Feasibility Study. J Clin Microbiol. 2012;50(2):246–57.
16. Stiasny A, Kuhn C, Mayr D, Alexiou C, Janko C, Wiest I, et al. Immunohistochemical Evaluation of E6 / E7 HPV Oncoproteins Staining in Cervical Cancer. Anticancer Res. 2016;3198:3195–8.
17. Arista A, Murtiastutik D, Setyaningrum T, Airlangga U, Hospital S. Genotyping of Human Papilloma Virus (HPV) in female condyloma acuminata patient in Dr. Soetomo Hospital, Surabaya. Dermatol Rep. 2019;11:89–90.
18. Liu G, Sharma M, Tan N, Barnabas R V. HIV-positive women have higher risk of human papilloma virus infection, precancerous lesions, and cervical cancer. AIDS. 2018;32(6):795–808.
19. Abel S, Najioullah F, Voluménie J-L, Accrombessi L, Carles G, Catherine D, et al. High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana. Andrei G, editor. PLoS One. 2019;14(9):e0221334.
20. Tobian AAR, Grabowski MK, Kigozi G, Gravitt PE, Eaton KP, Serwadda D, et al. High-risk human papillomavirus prevalence is associated with HIV infection among heterosexual men in Rakai, Uganda. Sex Transm Infect. 2013;89(2):122–7.
21. Kaderli R, Schnüriger B, Brügger LE. The impact of smoking on HPV infection and the development of anogenital warts. Int J Colorectal Dis. 2014;29(8):899–908.
22. Brianti P, De Flammineis E, Mercuri SR. Review of HPV-related diseases and cancers. New Microbiol. 2017;40(2):80–5.
23. Georgescu SR, Mitran CI, Mitran MI, Caruntu C, Sarbu MI, Matei C, et al. New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress. J Immunol Res. 2018;2018:1–10.
24. Gormley RH, Kovarik CL. Human papillomavirus–related genital disease in the immunocompromised host. J Am Acad Dermatol. 2012;66(6):883.e1-883.e17.
25. Patel H, Wagner M, Singhal P, Kothari S. Systematic review of the incidence and prevalence of genital warts. BMC Infect Dis. 2013;13(1):39.
26. Wieland U, Kreuter A, Pfister H. Human Papillomavirus and Immunosuppression. In 2014. p.154–65.
27. Grennan D. Genital Warts. JAMA. 2019;321(5):520.
28. Gheit T. Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology. Front Oncol. 2019;9:355.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Danu Yuliarto, Prasetyadi Mawardi, Muhammad Eko Irawanto
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
