A clinico-epidemiological study of acrochordons and their association with metabolic syndrome

Authors

  • Nisha Agrawal Assistant Professor, Department of Dermatology, JIS School of Medical Sciences & Research, India Array (unauthenticated)
  • Prabal Samanta Senior Resident, Department of Dermatology, School of Tropical Medicine, Kolkata, India. Array (unauthenticated)
  • Kingshuk Chatterjee Associate Professor, Department of Dermatology, NRS Medical College, India. Array (unauthenticated)
  • Jayanta Kumar Barua Associate Professor, Department of Dermatology, School of Tropical Medicine, Kolkata, India. Array (unauthenticated)
  • Gautam Banerjee Ex Professor and HOD Department of Dermatology, School of Tropical Medicine, Kolkata, India. Array (unauthenticated)

DOI:

https://doi.org/10.66344/jpad.33.3.2023.2158

Keywords:

Acrochordon, Skin tag, metabolic syndrome, Diabetes mellitus (DM), Obesity

Abstract

Achrochordons(Skin Tags) are common benign tumours occurring in skin of
the neck and flexural regions of the body.They most commonly occur in
middle age and old age population ranging from size of 1mm to 2-3cm in
diameter.The middle aged population most commonly seek treatment and older
people generally leave it attended.Cosmesis is the most common reason for
treatment,but they may sometimes cause chronic irritation due to pressure effect
or repeated friction.They can be multiple morphologies likel
filliform,pedunculated,sessile etc.They can be pigmented or of skin colour as
well.They don’t have any gender-predilection.
Metabolic syndrome is a curse of modern time.Genetic as well as lifestyle has
been implicated for the same.Diagnosis involves presence of 3 or more out of
Hyperglycemia,Hypertriglyceridemia,Decreased HDL Cholesterol
levels,Central obesity and Hypertension,according to guidelines laid by NCEP
ATP III guidelines.
Skin Tags is associated with the Metabolic syndrome in a significant number of
population.The co-existant population may have clinical manifestation of
Metabolic syndrome or may be having subclinical disease.So the presence of
Skin Tag can be used to screen patients for metabolic syndrome and may aid in
the detection of the subclinical cases as well.Early initiation of lifestyle
modification and therapy if required,may significantly decrease the morbidity
associated with the chronic disease.Hence it is advisable to be vigilant in
patients of Skin Tags,particularly in patients having more than 5 skin tags,and
investigate them for Metabolic syndrome so that we detect and treat them early.

References

Kahana M, Grossman E, Feinstein A, Ronnen M, Cohen M, Millet MS. Skin tags: A cutaneous marker for diabetes mellitus. Acta Derm Venereol. 1987;67:175–7.

Agarwal JK, Nigam PK. Acrochordon: A cutaneous sign of carbohydrate intolerance. Australas J Dermatol. 1987;28:132–3.

Mathur SK, Bhargava P. Insulin resistance and skin tags. Dermatology. 1997;195:184.

Rasi A, Soltani-Arabshahi R, Shahbazi N. Skin tag as a cutaneous marker for impaired carbohydrate metabolism: A case-control study. Int J Dermatol. 2007;46:1155–9.

AkpÑ–nar F, DervÑ–s E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol. 2012;22(1):106-10.

Demir S, Demir Y. Acrochordon and impaired carbohydrate metabolism. Acta diabetologica. 2002;39(2):57-9.

PubMed PMID: 12120914. https://doi.org/10.1007/s005920200014

Sari R, Akman A, Alpsoy E, Balci MK. The metabolic profile in patients with skin tags. Clin Exp Med. 2010;10(3):193-7.

doi: 10.1007/s10238-009-0086-5. Epub 2009 Dec 24.

Maluki AH, Abdullah AA. Metabolic Associations with Skin Tags. Int J Dermatol Clin Res. 2016;2(1):003-011.

Sudy E, Urbina F, Maliqueo M, Sir T. Screening of glucose/insulin metabolic alterations in men with multiple skin tags on the neck. J Dtsch Dermatol Ges. 2008; 6(10):852-5.

Tamega Ade A, Aranha AM, Guiotoku MM, Miot LD, Miot HA. [Association between skin tags and insulin resistance]. Anais Brasileiros de Dermatologia. 2010;85(1):25-31.

PubMed PMID: 20464083. Associacao entre acrocordons e resistencia a insulina.

Gorpelioglu C, Erdal E, Ardicoglu Y, Adam B, Sarifakioglu E. Serum leptin, atherogenic lipids and glucose levels in patients with skin tags. Indian J Dermatol. 2009; 54(1):20-2.

Erdogan BS, Aktan S, Rota S, Ergin S, Evliyaoglu D. Skin tags and atherosclerotic risk factors. J Dermatol. 2005;32(5):371-5.

El Safoury OS, Shaker OG, Fawzy MM. Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels. Indian J Dermatol. 2012;57:102-6.

Nicholas Angelopoulos, Anastasia Goula and George Tolis, Current knowledge in the neurophysiologic modulation of obesity. Metabolism. 2005;54(9):1202-17.

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Published

07.08.2023

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How to Cite

1.
A clinico-epidemiological study of acrochordons and their association with metabolic syndrome. J Pak Assoc Dermatol [Internet]. 2023 Aug. 7 [cited 2026 Jul. 21];33(3):935-42. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2158