Relationship between severity of psoriasis vulgaris based on Psoriasis Area And Severity Index (PASI) scores and depression
Keywords:
Beck Depression Inventory, depression, psoriasis vulgaris, psoriasis area and severity indexAbstract
Background Psoriasis vulgaris is a chronic inflammatory disease that attacks the skin and can manifest systemically. Psoriasis vulgaris patients usually have physical disabilities, social discomfort and psychological disorders. The psoriasis vulgaris patients have higher psychological comorbidities such as anxiety, depression and suicidal idea compared to the general population, by 40-90%. Objective To determine the relationship between psoriasis disease severity is based on PASI scores and depression. Methods An observational analytic study conducted on the psoriasis vulgaris patients at Dermatology and Venereology Department, Dr. Moewardi hospital in March-April 2022. Data collection and statistical analysis were carried out afterwards. All data were statistically analyzed using SPSS version 22 with Spearman rank test and p value <0.05 was considered to have a significant relationship. Results Most of the research subjects had mild PASI score of 54.2% and mild depression of 58.3%. The results of statistical tests showed significant relationship (p = 0.010) and moderate relationship (r = 0.513) between the psoriasis vulgaris severities based on the PASI score with depression. Conclusion The psoriasis vulgaris increases risk of depression. Higher severity of psoriasis vulgaris indicates higher depression behaviour. The psoriasis vulgaris and the depression are two-way relationship because the psoriasis vulgaris will stimulate the production of proinflammatory cytokines that trigger depression, while depression increases stress hormones due to the severity of psoriasis vulgaris.References
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