A rare association of squamous cell carcinoma with paraneoplastic pemphigus

Authors

  • Raavi Ramapure Jawaharlal Nehru medical college, sawangi
  • Vaishnavi Gulhane Jawaharlal Nehru medical college, sawangi
  • Sugat Jawade Jawaharlal Nehru medical college, sawangi
  • Adarshlata Singh Jawaharlal Nehru medical college, sawangi
  • Bhushan Madke Jawaharlal Nehru medical college, sawangi

DOI:

https://doi.org/10.66344/jpad.v32i2.1920

Abstract

Pemphigus vulgaris is an auto-immune blistering disorder associated with splitting at the dermo-epidermal junction. It targets the desmoglein structural protein of skin thus causing formation of blisters. It is seen to be associated with esophageal and laryngeal malignancies. Here in this case report, we try to highlight the unusual presentation of squamous cell carcinoma of buccal mucosa with pemphigus vulgaris.

References

1. Sendrasoa FA, Ranaivo IM, Rakotoarisaona MFl. Pemphigus vulgaris as the first manifestation of multiple myeloma: a case report. J Med Case Rep. 2018;12(1):255.

2. Porro AM, Seque CA, Ferreira MCC, Enokihara MMSES. Pemphigus vulgaris. An Bras Dermatol. 2019;94(3):264-78.

3. Mahomed Y, Mandel MA, Cramer SF, Michel B. Squamous cell carcinoma arising in pemphigus vulgaris during immunosuppressive therapy. Cancer. 1980;46(6):1374-7.

4. Sanders, WJ. A brief review of pemphigus vulgaris. Biomed Dermatol. 2017;1:7.

5. Didona D, Maglie R, Eming R, Hertl M. Pemphigus: Current and Future Therapeutic Strategies. Front Immunol. 2019;10:1418.

6. Takahashi O, Okushiba S, Kondo S, et al. Esophageal pemphigus vulgaris with carcinoma: postoperative steroid therapy based on pemphigus-related antibodies. Dis Esophagus. 2005;18(6):413-17.

7. Ingold CJ, Khan MAB. Pemphigus Vulgaris. [Updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560860/

8. Hammers CM, Stanley JR. Mechanisms of Disease: Pemphigus and Bullous Pemphigoid. Annu Rev Pathol. 2016;11:175-97.

9. Maglie R, Montefusco F, Senatore S, D'Erme AM, Bagnoni G, Antiga E. Localized pemphigus exacerbation associated with underlying breast cancer. JAAD Case Rep. 2020;6(12):1268-70.

10. Franziska Schauer, Norito Ishii, Maja Mockenhaupt, Leena Bruckner-Tuderman, Takashi Hashimoto, Dimitra Kiritsi1. Radiation-Associated Pemphigus Vulgaris in a Patient With Preceding Malignancy: Treatment With Rituximab as a Valuable Option. Front Immunol. 2020;10:3116.

11. Kridin K, Zelber-Sagi S, Comaneshter D, Cohen AD. Coexistent Solid Malignancies in Pemphigus: A Population-Based Study. JAMA Dermatol. 2018;154(4):435-40.

Downloads

Published

01.06.2022

Issue

Vol. 32 No. 2 (2022): April - June

Section

Case Reports

License

Copyright (c) 2022 Raavi Ramapure, Vaishnavi Gulhane, Sugat Jawade, Adarshlata Singh, Bhushan Madke

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Submission declaration

Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.

By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.

How to Cite

1.
A rare association of squamous cell carcinoma with paraneoplastic pemphigus. J Pak Assoc Dermatol [Internet]. 2022 Jun. 1 [cited 2026 Aug. 17];32(2):411-3. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1920