Comparison between efficacy of topical 1% ivermectin and topical 5% permethrin in the treatment of scabies

Abstract

Abstract: Background:  To compare the efficacy of topical permethrin 5% and topical ivermectin 1% in the treatment of scabies.   Methodology: Design: Experimental study/ Randomized control Trial study. Setting: Dermatology Department of Lahore General Hospital, Lahore. Duration: 31st January 2019 to 31st January’ 2020. Total 200 patients of 18-70 years age from both genders were enrolled, and divided into 2 groups: topical Ivermectin1% and topical permethrin 5% was given to group A and group B, respectively. The efficacy was noted by following the cases after every 2 weeks in outpatient department during 4-week treatment.      Results: Mean age of the patients from group A was 46.50±15.26 years, while from group B was 42.46±14.42 years. Male to female ratio was 0.47:1. Out of 200 patients, the remission was achieved in 188(94%) patients out of which 97 (97%) were from Permethrin group and 91(91%) were from Ivermectin group. The difference was statistically insignificant (p-value=0.074). Conclusion: Topical management of scabies with ivermectin 1% and permethrin 5% is equally beneficial.    Key Words: Ivermectin, Permethrin, Efficacy, Scabies