Sign of Leser-Trélat: An association with benign swellings
DOI:
https://doi.org/10.66344/jpad.24.1.2014.179Keywords:
Seborrheic keratosis, sign of Leser-Trélat, paraneoplastic, benignAbstract
Sign of Leser-Trélat (SLT) is defined by sudden eruption of numerous seborrheic keratosis or rapid increase in the number of pre-existing seborrheic keratosis. It has been reported as a paraneoplastic manifestation in literature but its position as a paraneoplastic manifestation has both strong opponents and proponents. We hereby, report a case of a 49-year-old male who presented to us with SLT-like lesions in association with benign swellings of neck and scrotum.ÂReferences
Wieland CN, Kumar N. Sign of Leser Trélat. Int J Dermatol. 2008;47:643-4
Zhang R, Zhu W. Seborrheic keratoses in five elderly patients: An appearance of raindrops and streams. Indian J Dermatol. 2011;56:432-4.
Heffernan MP, Khavari PA. Raindrop seborrheic keratoses: A distinctive pattern on the back of elderly patients. Arch Dermatol. 1998;134:382.
Garcia RL, Bishop ME. The rapid onset of seborrheic keratosis of the breasts during pregnancy. J Assoc Mil Dermatol. 1977;3:13-4.
Inamadar AC, Palit A. Eruptive seborrhoeic keratosis in human immunodeficiency virus infection: a coincidence or ‘the sign of Leser-Trélat’? Br J Dermatol. 2003;149:435-6.
Hsu C, Abraham S, Campanelli A et al. Sign of Leser-Trélat in a heart transplant recipient. Br J Dermatol. 2005;153:861-2.
Nanda A, Mamon HJ, Fuchs CS. Sign of Leser-Trélat in newly diagnosed advanced gastric adenocarcinoma. J Clin Oncol. 2008;26:4992-3.
Constantinou C, Dancea H, Meade P. The sign of Leser-Trélat in colorectal adenocarcinoma. Am Surg. 2010;76:340-1.
Patton T, Zirwas M, Nieland-Fisher N, Jukic D. Inflammation of seborrheic keratoses caused by cytarabine: a pseudo sign of Leser-Trélat. J Drugs Dermatol. 2004;3:565-6.
Ellis DL, Kafka SP, Chow JC et al. Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trélat, and multiple acrochordons: a possible role for alpha-transforming growth factor in cutaneous paraneoplastic syndromes. N Eng J Med. 1987;317:1582-7.
Birnie AJ, Varma S. A dermatoscopically diagnosed collision tumor: Malignant melanoma arising within a seborrheic keratosis. Clin Exp Dermatol. 2008;33:512-3.
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