Frequency of positive thyroid peroxidase antibody levels in patients of generalized vitiligo
DOI:
https://doi.org/10.66344/jpad.v31i4.1758Abstract
Objective To determine the frequency of positive thyroid peroxidase antibodies in patients of generalized vitiligo.
Methods This cross sectional study was conducted in the Dermatology Unit 1 of Jinnah Hospital, Lahore for a period of six months. 125 cases of generalized vitiligo, of both genders, ages between 15-60 years, and with any duration of disease were enrolled.
Results A total of 125 cases of generalized vitiligo were enrolled. 61.6% (n=77) patients were between 15-30 years of age whereas 38.4 % (n=48) were between 31-60 years of age, Mean was calculated as 31.56±7.77 years, 56.8% (n=71) were male and 43.2% (n=54) were females. Frequency of positive thyroid peroxidase antibodies in patients of generalized vitiligo was recorded in 32.8% (n=41).
Conclusion The frequency of positive thyroid peroxidase antibodies is significant in patients of generalized vitiligo.
References
1. Dash R, Mohapatra A, Manjunathswamy B. Anti-thyroid peroxidase antibody in vitiligo: A prevalence study. J Thyroid Res.2015:8 available from:
www.Hindwai.com/journals/jtr/2015/192736.[accress 13th May 2016]
2. Gee N, Speechaest R. Acquired Pigmentary Disorders. In:Griffiths C, Barker J, Bleiker T, Chalmers R et al. Rook’s text book of Dermatology 9th edition. UK, John Wiley and sons;2016.p.88.31-88.33
3. Butt G, Altaf F, Wazir U, Pal S. Familial frequency of vitiligo and its association with autoimmune disorder. J Pak Assoc Dermatol.2015;15:101-4.
4. Daneshpayhook M, Mostofizadeh M, Behjati J, Akhyani M, Robati R. Antithyroid peroxidase and vitiligo: a controlled study. BMC Dermatol.2006;6:3. Available from: https://bmcdermatol.biomedcentral.com/articles/10.1186/1471-5945-6-3[Accessed 13th May 2018]
5. Kalami T, Ohtaki S. Thyroid peroxidase. Rinsho Byori.1990;38(4):442-5.
6. Khalil A, Zaidman I, Bergman R. Autoimmune complications after hematopoietic stem cell transplantation in children with nonmalignant disorders. Sci World J.2014;2014:581657.
7. EH Kemp. Autoantibodies a diagnostic and predictive marker of vitiligo. Autoimmunity. 2004;37(4):287-90.
8. Gey A, Diallo A, Seneschal J. Autoimmune thyroid disease in vitiligo: multivariate analysis indicates intricate pathomechanisms. Br J Dermatol.2013; 168:756.
9. Sheth VM, Guo Y, Qureshi AA. Comorbidities associated with vitiligo: a ten-year retrospective study. Dermatology. 2013;227:311.
10. Vrijman C, Kroon MW, Limpens J. The prevalence of thyroid disease in patients with vitiligo: a systematic review. Br J Dermatol.2012;167:1224.
11. Dogra S., Parsad D., Handa S., Kanwar A. J. Late onset vitiligo: a study of 182 patients. Int J Dermatol.2005;44(3):193–6.
doi: 10.1111/j.1365-4632.2004.01948.x.
12. Majumder P. P., Nordlund J. J., Nath S. K. Pattern of familial aggregation of vitiligo. Arch Dermatol.1993;129(8):994–8.
doi: 10.1001/archderm.129.8.994.
13. Daneshpazhooh M, Mostofizadeh G, Behjati J, Akhyani M, Robati RM. Anti-thyroid peroxidase antibody and vitiligo: a controlled study. BMC Dermatol.2006;6:3.
14. Mandry RC, Ortiz LJ, Lugo-Somolinos A, Sanchez JL. Organ-specific autoantibodies in vitiligo patients and their relatives. Int J Dermatol.1996;35:18-21.
15. Morgan M, Castells A, Ramirez A. Autoantibodies in vitiligo: clinical significance. Med Cutan Ibero Lat Am. 1986;14:139-42.
16. Dave S, D'Souza M, Thappa DM, Reddy KS, Bobby Z. High frequency of thyroid dysfunction in Indian patients with vitiligo. Indian J Dermatol.2003;48:68-72.
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