Comparison of efficacy of 30% solution of trichloroacetic acid (TCA) with 0.025 % tretinoin in the treatment of flat warts at a tertiary care hospital
DOI:
https://doi.org/10.66344/jpad.v31i4.1739Abstract
Objective To compare the efficacy of 30% solution of trichloroacetic acid (TCA) with 0.025% tretinoin in the treatment of flat warts.
Methods This randomized controlled trial was conducted in department of dermatology, Nishtar Hospital Multan for a period of 6 months. A total of sixty patients meeting the inclusion criteria were randomly allocated in to two groups by lottery method. Group A, having 30 patients received 30% TCA topical application once weekly by the physician. In group B, 30 patients were asked to apply 0.025% tretinoin lotion, twice daily. The patients were followed up every 2 weeks for 12 weeks. Efficacy was noted at the end of 12 weeks.
Results Our study comprised of a total of 60 patients meeting inclusion criteria. Of these 60 study cases, 37 (61.7%) were male patients while 23 (38.3%) were female patients. Mean age of our study cases was 26.00±7.53 years. Mean no. of lesions was 7.23±2.89 and 51 (85.0%) patients had up to 10 lesions. Of these 60 study cases, 39 (65%) had lesions on face and 21 (35%) had lesions on the back of hand. Efficacy was noted in 43 (71.7%). In group A efficacy was noted in 27 (90%) while in group B, efficacy was 16 (53.3%).
Conclusion Efficacy of 30 % TCA was significantly higher as compared with 0.025% tretinoin. So, we support the use of 30% TCA in the treatment of flat warts in comparison with 0.025% tretinoin.
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