Imatinib mesylate induced pityriasis rubra pilaris like rash
DOI:
https://doi.org/10.66344/jpad.v31i4.1728Abstract
Pityrisis Rubra Pilaris (PRP) is an inflammatory keratinisation disorder with unknown etiology characterized by orange-red erythema, circumscribed keratosis, and branny scales, and palmoplantar keratoderma. There have been very few case reports which suggest drugs as an inciting or triggering factor for PRP. Imatinib is a Tyrosine Kinase inhibitor that is being used in several diseases notably chronic myeloid leukemia ( CML) and Gastrointestinal stromal tumors ( GIST). In this case report, we described a diagnosed case of CML with ABL-BCR positivity on oral Imatinib 400mg who developed generalized erythema with an orange hue and follicular keratosis with islands of normal skin. She was diagnosed as a case of PRP clinically and dermoscopically. Imatinib was stopped and she was started on 40 mg steroids which were tapered and stopped. The rash subsided in 1 week subsequently and did not recur in 6 months.
References
1. Griffiths WA. Pityriasis rubra pilaris. Clin Exp Dermatol.1980;5:105-12.
2. Plana A, Carrascora JM, Vilavella M, Ferrandiz C. Pityriasis rubra pilaris- like reactioninduced by imatinib. Clin Exp Dermatol.2013;38(5):520-22.
3. Paolini G, Didona D, Clerico R, Corsetti P et al. Skin lesions in patients treated with Imatinib mesylate: a 5-year Prospective study. Cutis.2016;97(6):E12-E16.
4. Errichetti E, Stinco G. The practical usefulness of dermoscopy in general dermatology. G Ital Dermatol Venereol. 2015;150(5):533-46.
5. Fuchs-Telem D, Sariag O, Vansteensel MA et al. Familial pityriasis rubra pilaris caused by mutations in CARD 14. Am J Hum Genet.2012;91:163-70.
6. Badri T, Zaouak A, Lakhoua G et al. Pityriasis rubra pilaris like eruption following insulin therapy initiation. Dermat Pract Concept.2016;6(4):4.
7. Brown S, Fletcher JW, Fiala KH. Bevacizumab-induced pityriasis rubra pilaris-like eruption. Proc (Bayl Univ Med Cent).2016;29(3):335-6.
8. Parz C, Querfeld C, Shea CR. Sorafenib-induced eruption resembling Pityriasis rubra pilaris. J Am Acad Dermatol.2011; 65(2):452-3.
9. Stalling SS, Vu JR, English JC. Teleprevir-induced pityriasis rubra pilaris-like drug eruption. Arch Dermatol.2012; 148(10):1215-17.
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