Can Hansen’s disease mimic histiocytosis? Histiocytosis a possibility in nonresponsive and incompletely investigated cases of Hansen’s disease
DOI:
https://doi.org/10.66344/jpad.v31i1.1523Keywords:
Generalized eruptive histiocytosis, histiocytosis, Hansen’s disease, histoid leprosy, skin colored papules.Abstract
Generalized eruptive histiocytosis (GEH) is a rare histiocytosis of the skin that presents in adults as multiple asymptomatic skin colored papules and nodules on the face, trunk and proximal upper limbs in a symmetrical manner. The lesions occur in crops and regress on their own. Clinical and histopathological examination differentiates this condition from other histiocytoses and from the more common disease leprosy, which it mimics closely. We describe a case of GEH mimicking Hansen’s disease (HD).
References
1. Tran TH, Pope E, Weitzman S. Cutaneous histiocytosis. In: Griffiths CEM, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Rook's Textbook of Dermatology. 9th ed. Oxford: Wiley Blackwell; 2016. p. 136.1-29.
2. Montero I, Gutiérrez-González R, Ginarte M, Toribio J. Generalized eruptive histiocytosis in a patient with chronic myelomonocytic leukemia. Actas Dermosifiliog 2012;103:643-4.
3. Emile JF, Alba O, Fraitag S, Home A, Haroche J, Donadieu J, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127:2672-81.
4. Marzano AV, Facchetti M, Caputo R. Guess what! Generalized eruptive histiocytosis (histiocytoma). Eur J Dermatol. 2002;12:205-6.
5. Klemke CD, Dippel E, Geilen CC, Koenigsmann MP, Thiel E, Orfanos CE, et al. Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia. J Am Acad Dermatol. 2003;49:S233-6.
6. Kaffenberger B, Darabi K, Peters S, Kynyk J, Bechtel M. Generalized eruptive histiocytomas and RosaiDorfman disease presenting concurrently in a patient with myelodysplastic syndrome. J Clin Aesthetic Dermatol. 2012;5:42-6.
7. Mahajan RS, Shah AC, Pasle RK, Bilimoria FE. Asymptomatic papular eruption in a 60 year old man. Indian J Dermatol. 2015;60:516-7.
8. Lan Ma H, Metze D, Luger TA, Steinhoff M. Successful treatment of generalized eruptive histiocytoma with PUVA. J Dtsch Dermatol Ges. 2007;5:131-4.
9. Tang X, Shen H, Xu A, Sun X, Wang Y, Shi G, et al. Spontaneous regression of generalized eruptive histiocytosis: Possible involvement of apoptosis? Int J Dermatol. 2007;46:1073-5.
10. Deng YJ, Hao F, Zhou CL, Sun RS, Xiang MM, Wang JW. Generalized eruptive histiocytosis: a possible therapeutic cure? Br J Dermatol. 2004;150:171-3.
11. Goodman WT, Barrett TL. Histiocytoses. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. 3rd ed. Philadelphia: Elsevier Saunders; 2012. p. 1529-46.
12. Caputo R, Marzano AV, Passoni E, Berti E. Unusual variants of nonlangerhanscell histiocytoses. J Am Acad Dermatol. 2007;57:1031-45.
13. Ruíz GA, Ruíz BA, Fraile AH, Martinez PI, Muñoz GM. Progressive nodular histiocytosis accompanied bysystemic disorders. Br J Dermatol. 2000;143:628-31.
14. Rao AG, Lakshmi TS, Vani V. Multicentric reticulohistiocytosis. Indian J Dermatol Venereol Leprol. 2003;69:35-6.
15. Verma SB. Generalized eruptive histiocytomasand juvenile eruptive xanthogranulomas in a 10-year-old boy: a potpourri of exotic terms indicatingthe need for unification. Int J Dermatol. 2012;51:445-7.
16. Sharath Kumar BC, Nandini AS, Niveditha SR, Gopal MG, Reeti. Generalized eruptive histiocytosis mimicking leprosy. Indian J Dermatol Venereol Leprol. 2011;77:498-502.
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