Hypomelanosis of Ito with neurological involvement

Authors

  • Iti Varshney Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
  • Mohammad Adil Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India http://orcid.org/0000-0002-8697-1451
  • Syed Suhail Amin Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
  • Mohd Mohtashim Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
  • Roopal Bansal Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
  • Hania Qamar Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Keywords:

Hypomelanosis of Ito, Incontinentia Pigmenti Achromicans, neurocutaneous syndrome, white matter atrophy

Abstract

Hypomelanosis of Ito is also known as Incontinentia pigmenti achromians because the distribution of depigmented lesions is the negative image of hyperpigmented streaks of Incontinentia pigmenti. We report an infant of 9 months with hypopigmented macules along blaschkoid lines, developmental delay, macrocephaly and seizures. MRI brain revealed white matter atrophy and prominent temporal horns of lateral ventricles. This case report highlights the coexistence of Hypomelanosis of Ito with neurological involvement and thus the need to differentiate it from other similar conditions presenting with Blaschkoid dyspigmentation. 

Author Biographies

Iti Varshney, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Junior Resident,Department of Dermatology,J.N. Medical College, AMU, Aligarh

Mohammad Adil, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Assistant Professor,Department of Dermatology,J.N. Medical College, AMU, Aligarh

Syed Suhail Amin, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Professor & Chairman,Department of Dermatology,J.N. Medical College, AMU, Aligarh

Mohd Mohtashim, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Senior Resident,Department of Dermatology,J.N. Medical College, AMU, Aligarh

Roopal Bansal, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Senior Resident,Department of Dermatology,J.N. Medical College, AMU, Aligarh

Hania Qamar, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Junior Resident,Department of Dermatology,J.N. Medical College, AMU, Aligarh

References

Pavone P, Praticò AD, Ruggieri M, Falsaperla R. Hypomelanosis of Ito: a round on the frequency and type of epileptic complications. Neurol Sci 2015; 36: 1173.

Geetha K, Priya G L, Rameshwari T. Hypomelanosis of Ito associated with cafe-au-lait spot and angiomatous nevi. Indian J Paediatr Dermatol 2015; 16: 221-3.

Pascual-Castroviejo I, Lopez-Rodrigucz L, de la Cruz Medina M, Salamanca-Maesso C, Roche Herrero C; Hypomelanosis of Ito, Neurological complications in 34 cases; Can J Neurol Sci. 1998; 5: 124-9.

Nehal KS, PeBenito R, Orlow SJ. Analysis of 54 cases of hypopigmentation and hyperpigmentation along the lines of Blaschko. Arch Dermatol. 1996; 132(10):1167-70.

Ross DL, Liwnicz BH, Chun RW, Gilbert E. Hypomelanosis of Ito (incontinentia pigmenti achromians)--a clinicopathologic study: macrocephaly and gray matter heterotopias. Neurology 1982; 32: 1013-6.

Saha A, Seth J, Mukherjee S, Basu S. Hypomelanosis of Ito with brain abscess: An incidental association or consequence of underlying structural defect. Indian J Paediatr Dermatol 2015; 16: 186-8.

Trägårdh M, Thomsen CR, Thorninger R, Møller-Madsen B. Hypomelanosis of Ito presenting with pediatric orthopedic issues: a case report. J Med Case Rep 2014; 8:156.

El-Sawy T, He L, Chiang MF, Anyane-Yeboa K, Morel KD, Folberg R, et al. Retinoblastoma presenting in a child with hypomelanosis of Ito. Open Ophthalmol J. 2011; 5: 55-8.

Ruiz-Maldonado R, Toussaint S, Tamayo L, Laterza A, del Castillo V. Hypomelanosis of Ito: diagnostic criteria and report of 41 cases. Pediatr Dermatol 1992; 9: 1-10.

Cohen J 3rd, Shahrokh K, Cohen B. Analysis of 36 cases of Blaschkoid dyspigmentation: reading between the lines of Blaschko. Pediatr Dermatol 2014; 31: 471-6.

Downloads

Published

2019-10-22

How to Cite

1.
Varshney I, Adil M, Amin SS, Mohtashim M, Bansal R, Qamar H. Hypomelanosis of Ito with neurological involvement. J Pak Assoc Dermatol [Internet]. 2019Oct.22 [cited 2024Nov.8];29(4):433-5. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1360

Most read articles by the same author(s)

1 2 > >>