Frequency of Helicobacter pylori infection in patients of chronic spontaneous urticaria
Keywords:
Chronic spontaneous urticaria, H pylori, stool for H pylori antigen, frequencyAbstract
Objective To calculate the frequency of Helicobacter pylori infection by stool antigen assays in patients of chronic spontaneous urticaria. Methodology The study was cross-sectional & conducted in Dermatology outpatient department of Saifee Hospital Trust, Karachi, Pakistan. The duration of study was six months i.e. from July 1st 2017 to December 31st 2017. Clinically diagnosed, 130 adult cases of chronic spontaneous urticaria of either gender, age 18 years and above, having urticaria for 6 months or more were included via non-probability consecutive sampling technique. Stool for H pylori antigen assays were performed and results were recorded. Results In our study, the mean age was 33.4 ± 13.0 years. Mean duration of symptoms was 1.5 years. Out of 130 patients, 98 (75.4%) were female and 32 (24.6%) were male with a female to male ratio of 3:1. In our study, those who have urticaria for longer duration (more than 1 year) were more likely to have H pylori infection as compared to those who have shorter duration (P=<0.009). Overall, stool for H pylori antigen test was positive in 39 (30%) patients with urticaria (P=<0.001). Conclusion The number of cases with positive stool for H pylori antigen among chronic spontaneous urticaria patients is significantly higher and it is one of the main aetiopathogenic factors for this disease. Cases of urticaria should be routinely screened for H pylori infection and eradication therapy will be useful for control of disease.References
Mariyath OKR, Binitha MP, Anilakumari VP, Biju G, Nikhila PK, Pradeep M. Association between chronic spontaneous urticaria and thyroid autoimmunity: a case control study from a tertiary care centre. Int J Res Dermatol 2017; 3(1): 64-8.
Kim DH, Sung NH, Lee AY. Effect of levothyroxine treatment on clinical symptoms in hypothyroid patients with chronic urticaria and thyroid autoimmunity. Ann Dermatol 2016; 28(2): 199-204.
Kohli S, Mahajan VK, Rana BS, Mehta KS, Raina RK, Chauhan PS, et al. Clinicoepidemiologic features of chronic urticaria in patients with versus without subclinical helicobacter pylori infection: a cross-sectional study of 150 patients. Int Arch Allergy Immunol 2018; 175(1-2): 114-20.
Grattan CEH, Marsland AM. Urticaria. In: Griffiths CEM, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Rook’s textbook of dermatology. Vol 2. 9th ed Oxford: Wiley-Blackwell; 2016 p. 42.1-18.
Ifeanyichukwu OK, Herrienta OO, Gabriel ABI, Nnana II, Uchechukwu D. Comparative evaluation of stool antigen immunoassay and blood antibody test methods for the screening of Helicobacter pylori infection in asymptomatic adult population in Delta state, Nigeria. J Mol Microbiol 2018; 2(1:3): 1-7.
Bashir AHH, Yousif SM, Mahmoud MOA. Clinicoepidemiological study in Sudanese patients: prevalence and effect of eradicative triple therapy on extra digestive Helicobacter pylori skin manifestations, EdHpSm. Clin Rev Opin 2011; 3(2): 14-9.
Shakouri A, Compalati E, Lang DM, Khan DA. Effectiveness of Helicobacter pylori eradication in chronic urticaria: evidence-based analysis using the grading of recommendations assessment, development, and evaluation system. Curr Opin Allergy Clin Immunol 2010; 10(4): 362-9.
Pawłowicz R, Wytrychowski K, Panaszek B. Eradication of Helicobacter pylori, as add-on therapy, has a significant, but temporary influence on recovery in chronic idiopathic urticaria: a placebo-controlled, double blind trial in the Polish population. Postepy Dermatol Alergol 2018; 35(2): 151-5.
Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G. Diagnosis of Helicobacter pylori: What should be the gold standard? World J Gastroenterol 2014; 20(36): 12847-59.
Mogaddam MR, Yazdanbod A, Ardabili NS, Maleki N, Isazadeh S. Relationship between Helicobacter pylori and idiopathic chronic urticaria: effectiveness of Helicobacter pylori eradication. Postep Derm Alergol 2015; 32(1): 15-20.
Gu H, Li L, Gu M, Zhang G. Association between helicobacter pylori infection and chronic urticaria: a meta-analysis. Gastroenterol Res Pract 2015; 4869-74.
Tüzün Y, Keskin S, Kote E. The role of Helicobacter pylori infection in skin diseases: facts and controversies. Clin Dermatol 2010; 28(5): 478-82.
Akashi R, Ishiguro N, Shimizu S, Kawashima M. Clinical study of the relationship between helicobacter pylori and chronic urticaria and prurigo chronica multiformis: effectiveness of eradication therapy for helicobacter pylori. J Dermatol 2011; 38: 761-6.
Albisher AM, Alharbi MH, Albisher MM. Relationship between helicobacter pylori, chronic idiopathic urticaria and atopic dermatitis. Egypt J Hosp Med 2018; 70(11): 1921-4.
Jørgensen AR, Egeberg A, Gideonsson R, Weinstock LB, Thyssen EP, Thyssen JP. Rosacea is associated with Helicobacter pylori: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 2017; 31(12): 2010-15.
Yang X. Relationship between Helicobacter pylori and Rosacea: review and discussion. BMC Infect Dis 2018; 18(1): 318.
Magen E, Delgado JS. Helicobacter pylori and skin autoimmune diseases. World J Gastroenterol 2014; 20(6): 1510-6.
Talley NJ, Vaki NB. Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol 2005; 100(10): 2324-37.
Muhemmed FR, Ali KBM. Association of chronic urticaria with Helicobacter Pylori infection in Erbil: a case control study. Zanco J Med Sci 2006; 20(2): 1376-84.
Tareen A, Butt T, Ali B. Helicobacter pylori infection in patients with chronic urticaria and dyspepsia, experience from a developing country. J Pak Assoc Derma 2016; 26(3): 206-13.
Rostamy MM. Prevalence of the Helicobacter pylori infection in chronic urticaria. J Pak Assoc Derma 2010; 20: 142-5.
Yadav MK, Rishi JP, Nijawan S. Chronic urticaria and helicobacter pylori. Indian J Med Sci 2008; 62(4): 157-62.
Sianturi GN, Soebaryo RW, Zubier F, Syam AF. Helicobacter pylori Infection: prevalence in chronic urticaria patients and incidence of autoimmune urticaria. Acta Med Indones 2007; 39(4): 157-62.
Inoue K, Tani M, Yoshihara M. Investigation of Helicobacter pylori stool antigen test in comparison with gastric endoscopy and serum pepsinogens. Nihon shokaki shudan kenshin gakkai zashi Journal of Gastroenterological Mass Survey 2005; 43(6): 623-9. (In Japanese.)
Mosbeh AS, Aladl A, Tealeb AS, Ali MS. Role of helicobacter pylori in chronic urticaria among egyptian patients with dyspepsia: a case–control study. Int J Dermatol Clin Res 2017; 3(1): 26-31.
