Prevalence of thyroid disorders in patients with alopecia areata
Keywords:
Alopecia areata, thyroid disorders, autoimmune disordersAbstract
Objective To study the prevalence of autoimmune thyroid disorders – thyroid auto-antibodies in patients with alopecia areata (AA) in Kerman, a city in South-East part of Iran. Methods 52 patients with AA from those attending the dermatology ward of Afzalipour hospital in Kerman were enrolled. An equal number of age- and sex-matched controls (n=52) was included. Physical examination of thyroid was done for all patients and controls. The rate of positivity of anti-thyroid peroxidase (TPO) antibodies and abnormal thyroid hormone levels in both groups were measured and compared. Results In both cases and controls, 48.1% and 51.9 % were males and females, respectively. The mean age in group of cases and control groups were 30.55 and 31.80 years, respectively. The number of lesions ranged from 1 to 10, and the duration of disease ranged from 0.6 to 96 months. No meaningful statistical difference was seen between prevalence of thyroid disorders in patients of AA and controls. Conclusion In this study no correlation between AA and thyroid disorders was noted.References
Wasserman D, Guzman-Sanchez DA, Scott D, McMichael A. Alopecia areata. Int J Dermatol. 2007;46:121-31.
Kavak A, Yesildal N, Parlak A et al. Alopecia areata in Turkey: demographic and clinical features. J Eur Acad Dermatol Venereol. 2008;22:977 81.
Gulec AT, Tanriverdi N, Duru C et al. The role of psychological factors in alopecia areata and the impact of the disease on the quality of life. Int J Dermatol. 2004;43:352-6.
Goh C, Finkel M, Christos PJ, Sinha AA. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol. 2006;20:1055-60.
Martinez-Mir A, Zlotogorski A, Ott J et al. Genetic linkage studies in alopecia areata. J Invest Dermatol Symp Proc. 2003;8:199-203.
Hordinsky M, Ericson M. Autoimmunity: alopecia areata. J Invest Dermatol Symp Proc. 2004;9:73-8.
Milgraum SS, Mitchell AJ, Bacon GE, Rasmussen JE. Alopecia areata, endocrine function, and autoantibodies in patients 16 years of age or younger. J Am Acad Dermatol. 1987;17:57-61.
Kavak A, Yesildal N, Parlak A et al. Alopecia areata in Turkey: demographic and clinical features. J Eur Acad Dermatol Venereol. 2008;22:977 81.
Kasumagić-Halilović E. Thyroid autoimmunity in patients with alopecia areata. Acta Dermatovenerol Croat. 2008;16:123-5.
Puavilai S, Puavilai G, Charuwichitratana S et al. Prevalence of thyroid diseases in patients with alopecia areata. Int J Dermatol. 1994;33:632-3.
Corazza GR, Andreani ML, Venturo N et al. Celiac disease and alopecia areata: report of a new association. Gastroenterology. 1995;109:1333-7.
Kasumagic-Haliovic E. Thyroid autoimmunity in alopecia areata. Acta Dermatovenereol Croat. 2008;16:123-5.
Seyrafi H, Akhiani M, Abbasi H et al. Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients. BMC Dermatol. 2005;5:11.
Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol. 1996;35:22-7.
De Waard-van der Spek FB, Oranje AP, De Raeymaecker DM, Peereboom-Wynia JD. Juvenile versus maturity-onset alopecia areata--a comparative retrospective clinical study. Clin Exp Dermatol. 1989;14:429.
Ghalamkar F, Mohsenzadeh M, Velai N. Evaluation of relationship between thyroid diseases and alopecia areata. Pejouhandeh. 2001;6:1-15.