Frequency of steroid induced hyperglycemia in patients with dermatological disorders
Keywords:
Steroid-induced hyperglycemia, frequency, dermatological disordersAbstract
Objective To assess the frequency of steroid-induced hyperglycemia in patients taking systemic steroids (30mg or more of prednisolone or equivalent) for dermatological disorders. Methods We included 150 patients of either sex and with ages between 12 and 70 years in this cross-sectional study, carried out in the department of dermatology, Jinnah Hospital, Lahore for a duration of 6 months. Their baseline fasting blood glucose level prior to the start of steroid treatment was recorded. Patients taking 30mg or more of prednisolone (or equivalent) were followed up after one week of treatment and their random blood sugar levels were checked by the same laboratory on venous blood, to see whether they developed hyperglycemia or not after treatment with steroids. Results Mean age of the patients was 41.83±16.42 years. Ninety-four (62.7%) patients were male while 56 (37.3%) were female. Hyperglycemia was found in 28 out of 150 (18.7%) patients. Conclusion Steroid induce hyperglycemia occurred in 18.7% of the study population.References
van Raalte D. Steroid diabetes. [Online] Available from: http://www.diapedia.org/other-types-of-diabetes-mellitus/steroid-diabetes/[Accessed 17th February 2014].
Oakley A. Systemic Steroids. [Online] Available from: http://www.dermnetnz.org/treatments/systemic-steroids.html/[Accessed 17th February 2014].
Clore JN, Thurby-Hay L. Glucocorticoid-induced hyperglycemia. Endocr Pract. 2009;15:469-74.
Lansang M. Glucocorticoid-induced diabetes and adrenal suppression: How to detect and manage them. Clev Clin J Med. 2011;78:748-56.
Priti D, Asawari R, Arundhati D, Kushal G, Aeyna T. A prospective study of steroid induced hyperglycaemia. J Med Sci Res. 2011;2(1):46-49.
Panthakalam S, Bhatnagar D, Klimiuk P. The prevalence and management of hyperglycaemia in patients with rheumatoid arthritis on corticosteroid therapy. Scott Med J. 2004;49:139-41.
Kim SY, Yoo CG, Lee CT, Chung HS, Kim YW, Han SK et al. Incidence and risk factors of steroid-induced diabetes in patients with respiratory disease. J Korean Med Sci. 2011;26: 264-6.
Uzu T, Harada T, Sakaguchi M, Kanasaki M, Isshiki K, Araki S et al. Glucocorticoid induced diabetes mellitus: prevalence and risk factors in primary renal diseases. Nephron Clin Pract. 2007;105:c54–c57.
Hjelmesaeth J, Hartmann A, Kofstad J, Stenstrom J, Leivestad T, Egeland T et al. Glucose intolerance after renal transplantation depends upon prednisolone dose and recipient age. Transplantation. 1997;64:979-83.
Binnert C, Ruchat S, Nicod N, Tappy L. Dexamethasone-induced insulin resistance shows no gender difference in healthy humans. Diabetes Metab. 2004;30:321-6.
Raúl Ariza-Andraca C, Barile-Fabris LA, Frati-Munari AC, Baltazár-Montufar P. Risk factors for steroid diabetes in rheumatic patients. Arch Med Res. 1998;29:259-62.