Necrolytic acral erythema: an unusual cutaneous presentation of hepatitis C virus infection
Keywords:
Necrolytic acral erythema, hepatitis C virus infectionAbstract
Necrolytic acral erythema (NAE) is a newly recognized dermatosis which has been regarded as early cutaneous marker of hepatitis C virus (HCV) infection. It presents as a well demarcated, dusky, symmetrically distributed erythematous to violaceous eruption with marked hyperkeratosis and lichenification associated with pruritus or burning on the dorsal aspects of feet extending to the toes. It shows clinical and histopathological resemblance to other necrolytic erythemas. We report a case of a-55-year-old woman with itchy hyperpigmented papules and plaques on the feet for the last 6 months. Histopathology showed the features of necrolytic acral erythema.References
El Darouti M, Abu el Ela M. Necrolytic acral erythema: a cutaneous marker of viral hepatitis C. Int J Dermatol 1996;35:252-6.
Najarian DJ, Lefkowitz I, Balfour E et al. Zinc deficiency associated with necrolytic acral erythema. J Am Acad Dermatol 2006;55(5 Suppl):S108-10.
Tabibian JH, Gerstenblith MR, Tedford RJ et al. Necrolytic acral erythema as a cutaneous marker of hepatitis C: report of two cases and review. Dig Dis Sci 2010; 55:2735-43.
El-Darouti MA, Mashaly HM, El-Nabarawy E et al. Leukocytoclastic vasculitis and necrolytic acral erythema in patients with hepatitis C infection: do viral load and viral genotype play a role? J Am Acad Dermatol 2010;63:259-65.
El-Ghandour TM, Sakr MA, El-Sebai H et al. Necrolytic acral erythema in Egyptian patients with hepatitis C virus infection. J Gastroenterol Hepatol 2006;21:1200-6.
Abdallah MA, Ghozzi MY, Monib HA et al. Histological study of necrolytic acral erythema. J Ark Med Soc 2004;100:354-5.
Khanna VJ, Shieh S, Benjamin J et al. Necrolytic acral erythema associated with hepatitis C: effective treatment with interferon alfa and zinc. Arch Dermatol 2000;136:755-7.
Liu A, Erickson CP, Cockerell CJ, Hsu S. Necrolytic acral erythema: a case not associated with hepatitis C infection. Dermatol Online J 2008;14:10.
Abdallah MA, Hull C, Horn TD. Necrolytic acral erythema: a patient from the United States successfully treated with oral zinc. Arch Dermatol 2005;141:85-7.
Khokhar N, Gill ML, Malik GJ. General seroprevalence of hepatitis C and hepatitis B virus infections in population. J Coll Physicians Surg Pak 2004, 149:534-6.
Syed AA, Rafe MJ, Qureshi H, Vermund SH. Hepatitis B and hepatitis C in Pakistan. Int J Infect Dis 2009;13:9-19.
