Chronic urticaria: frequency of anti-HCV antibodies

Authors

  • Ijaz Ahmed
  • Zarnaz Wahid
  • Zaffar Ahmed

Keywords:

Hepatitis C virus, hepatitis B virus, urticaria, anti-HCV antibodies, seropositive

Abstract

Background Urticaria is defined as a skin disorder, clinically characterized by the presence of transient erythematous itchy weals presenting as an acute or a chronic disease, which may be caused by a wide variety of factors. Among infectious causes, hepatitis B virus is a known cause of urticaria; it would not be surprising if hepatitis C virus turns out to be an important one as well. The current study was aimed to determine the frequency of anti-BCV antibodies and HCV RNA in patients with chronic urticaria and to study HCV as a cause of urticaria. Patients and methods Of all the clinically diagnosed cases of chronic urticaria presenting in the outpatient department of Baqai Institute of Skin Diseases, patients fulfilling the inclusion criteria were enrolled in the study from 1st January, 2002 till 30th June, 2003 over a period of eighteen months. Patients belonging to either sex were aged 11 to 55 years. A written consent was taken from all the enrolled patients to carry out various blood tests. Sera of all the enrolled patients were tested for anti-HCV antibodies. Patients with positive enzyme-linked immunosorbent assay were also tested for viral RNA in their blood (polymerase chain reaction). Other relevant investigations were also carried out in seropositive patients i.e. liver function tests and ultrasound abdomen. Results Of the 114 patients enrolled in the study, 51 (44.8%) were males and 63 (55.2%) females, the gender ratio being 0.8. The maximum age of presentation was 55 years while minimum was 11 years. Maximum number of patients was 21-30 years of age (42.1%). Fifteen patients (13.2%) were positive for anti-HCV antibodies, comprising 9 females (7.8%) and 6 (5.6%) males (p<0.003). Maximum number of these patients (7.1%) was aged 21-30 years. Five (4.4%) of these seropositive subjects were also positive for HCV RNA including three males (2.6%) and two (1.8%) females. Deranged liver function tests were a feature in only 2 of these patients. Conclusion There may be a significant association of chronic urticaria with anti-HCV antibodies. Further studies are necessary to establish or refute an aetiopathogenetic role of HCV in this condition. 

References

Kanazawa K et al. Hepatitis C virus infection in patients with urticaria. J Am Acad Dermatol 1996; 35: 195-8.

Reichel M, Mauro TM. Urticaria and hepatitis C. Lancet 1990; 336: 822-3.

Hadziyannis SJ. Skin diseases associated with hepatitis C virus infection. J Eur Acad Dermatol Venereol 1998; 10: 12-21.

Chuang TY, Stitle L, Brashear R, Lewis C. Hepatitis C virus and lichen planus: a case-controlled study of 340 patients. J Am Acad Dermatol 1999; 41: 787-9.

Chuang TY, Brashear R, Lewis C. Porphyria cutanea tarda and hepatitis C virus: A case-controlled study and meta-analysis of the literature. J Am Acad Dermatol 1999; 41: 31-6.

Smith R, Caul EO, Burton JL. Urticaria and hepatitis C (letter). Br J Dermatol 1997; 136: 980.

Doutre MS, Beylot-Barry M, Beylot C. Urticaria and hepatitis C infection. Br J Dermatol 1998; 138: 194-5.

Llanos F, Raison-Peyron N, Meunier L et al. Hepatitis C virus infection in patients with urticaria (letter). J Am Acad Dermatol 1998; 38: 646.

Mahboob A, Haroon TS, Iqbal Z et al. Frequency of anti-HCV antibodies in patients with lichen planus. J Coll Physicians Surg Pak 2003; 13: 248-52.

Alter MJ. Sporadic non-A, non-B, frequency and epidemiology in urban US population. J Infect Dis 1982; 145: 886-93.

Perez Romero M, Sanchez Qugano A, Lissen E. Transmission of hepatitis C virus (letter). Ann Intern Med 1990; 113: 411.

Alter MJ, Coleman PJ. Importance of heterosexual activity in the transmission of hepatitis B and non-A, non-B hepatitis. J Infect Dis 1982; 146: 901-4.

Thaler MM, C, Landers DV. Vertical transmission of hepatitis "C" virus. JAMA 1990; 265: 1263-4.

Alter MJ, Margolis S, Krwaczynski K, Judson FN, Mares A. The natural history of community acquired hepatitis "C" in the United States. N Eng J Med 1992; 327: 1899-1905.

Mattson L, Weiland O, Glaumann H. Long term follow up of chronic posttransfusion non-A, non B, hepatitis; clinical and histological outcome. Liver 1988; 8: 184-8.

Malik L, Ahmed N, Butt SA et al. The role of hepatitis "C" virus in the aetiology of hepatocellular carcinoma in northern Pakistan- a preliminary report. J Coll Physicians Surg Pak 1995; 5: 26-8.

Umar M, Hamama Tul Bushra, Shuaib A, Shah NH. Spectrum of chronic liver disease due to hepatitis "C" virus infection. J Coll Physicians Surg Pak 2000; 10: 380-3.

Hashmi ZI, Chaudry A, Ahmad M. Healthy volunteer blood donors; incidence of anti-HCV antibodies. Prof Med J 1999; 6: 551-5.

Bhopal FG, Yusuf A, Taj MN, Iqbal M. Frequency of hepatitis "B and C": surgical patients in Rawalpindi General Hospital. Prof Med J 1999; 6: 502-9.

Tufail HM, Shaukat A, Chaudry A et al. Hepatitis "B and C" virus and nephritic syndrome. Prof Med J 2000; 7: 207-12.

Shafi T, Iqbal J, Ahmad S. Prevalence of anti-HCV antibodies in hemodialysis patients. Pak J Med Res 1992; 31: 42-5.

Tariq WUZ, Hassan SZU. Prevalence of viral hepatitis "C" in chronic liver disease in Pakistan (abstract). The Ninth Medical Conference of Kuwait Medical Association 1994.

Cribier BJ, Santinelli F, Schmitti C et al. Chronic urticaria is not significantly associated with hepatitis C or hepatitis G infection. Arch Dermatol 1999; 135: 1335-9.

Dega H, Frances C, Dupin N et al. Pruritus and the hepatitis "C" virus. The MULTIVIRC Unit. Ann Dermatol Venereol 1998; 125: 9-12.

Karlisberg PL, Lee WM, Casy DL et al. Cutaneous vasculitis and rheumatoid factor positivity as presenting signs of hepatitis C virus-induced mixed cryoglobulinemia. Arch Dermatol 1995; 131: 1119-23.

Kanazawa K, Yaoita H, Tsuda F, Okamoto H. Hepatitis "C" virus infection in patients with urticaria. J Am Acad Dermatol 1996; 35:195-8.

Tameez ud deen, Naqqash S, Butt AQ. Lichen planus and hepatitis "C" virus infection: An epidemiological study. J Pak Assoc Dermatol 2003; 13: 127-9.

EL Kabeer M, Scully C, Porter S et al. Liver function in UK patients with oral lichen planus. Clin Exp Dermatol 1993; 18: 12-6.

Doutre MS. Hepatitis C virus related skin diseases. Arch Dermatol 1999; 135: 1401-3.

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Published

2017-01-03

How to Cite

1.
Ahmed I, Wahid Z, Ahmed Z. Chronic urticaria: frequency of anti-HCV antibodies. J Pak Assoc Dermatol [Internet]. 2017Jan.3 [cited 2024Nov.4];13(4):179-83. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/760

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