Comparative efficacy of filtered blue light (emitted from sunlight) and topical erythromycin solution in acne treatment: a randomized controlled clinical trial
Keywords:
Acne, blue light, phototherapyAbstract
Background Acne vulgaris is one of the commonest skin conditions .The visible light has attracted attention as a new and safe therapeutic option, as some studies show more than 80% response to 420 nm phototherapy with a significant reduction in inflammatory acne lesions after only eight treatments. Patients and methods We evaluated the use of blue light and topical erythromycin in 32 acne patients. The right-sided lesions were treated with erythromycin solution twice daily and the left ones were treated with irradiation of sunlight by a filter for 15 minutes once daily for 8 weeks and in another treatment group, the lesions in sides of the face were treated on reverse manner. Results The difference between the treatment and control sides was not significant at week 4, and 8 (p>.05). After 12 weeks of starting the program, a mean improvement of 20% in lesion counts was achieved by the blue light phototherapy. In our study, a mean improvement of 46% in acne score was achieved with the blue light compared to 58% with topical erythromycin (p>0.05). Conclusion We found that visible light phototherapy improved partially acne lesions and may be an appealing noninvasive alternative for the treatment of acne,ÂReferences
McGinley KJ, Webster GF, Leyden JJ. Facial follicular porphyrin fluorescence. Correlation with age and density of Propionibacterium acnes. Br J Dermatol 1980; 102: 437-41.
Elman M, Slatkin M, Harth YJ. The effective treatment of acne vulgaris by a high-intensity narrow band 405-420nm light source. Cosmet Ther 2003; 5: 111-7.
Kjeldstad B. Photoinactivation of Propionibacterium acnes by near ultraviolet light. Z Naturforsch 1984; 39: 329-35.
Papageorgiou P, Katsambas A, Chu A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol 2000; 142: 973-8.
Breitbart H, Levinshal T, Cohen N et al. Changes in calcium transport in mammalian sperm mitochondria and plasma membranes irradiated at 633 nm (He-Ne laser). J Photochem Photobiol 1996; 34: 117-21.
Iusim M, Kimchy J, Pillar T et al. Evaluation of the degree of effectiveness of Biobeam (low level narrow band light) on the treatment of skin ulcers and delayed post-operative wound healing. Orthopedics 1992; 15: 1023-6.
Morton CA, Scholefield RD, Whitehurst C, Birch J. An open study to determine the efficacy of blue light in the treatment of mild to moderate acne. J Dermatol Treat 2005; 16: 219-23.
Goldberg DJ, Russell BA. Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne vulgaris. J Cosmet Laser Ther 2006; 8:71-5.
Haedersdal M, Togsverd-Bo K, Wulf HC. Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris. J Eur Acad Dermatol Venereol 2008; 22: 267-78.
