Efficacy and side effects estimation of 5% dapsone gel in the treatment of mild to moderate acne vulgaris
Keywords:
acne vulgaris, 5% Dapsone gelAbstract
Background: Acne vulgaris is a disorder of inflammation of pilosebaceous unit, clinically manifest as comedones, papules, nodules and cystic leisons affecting most commonly face and upper trunk.5% Dapsone gel is approved to treat acne vulgaris. Methods: Interventional study was conducted during 6 months period in dermatology out patient department of Akhtar Saeed medical and dental college, Lahore. Patients were enrolled in the study considering inclusion criteria. They were asked to apply 5 % Dapsone gel twice daily on the face for 3 months. They were followed up every 2 weeks to look for possible response to topical gel. Investigator Global acne severity assessment scale was used. Efficacy was also evaluated by mean percent reduction of lesions. Side effects estimation like burning, stinging, erythema and dryness was noted. Results: At the end of 12 weeks, 5 % Dapsone gel was effective in reduction of inflammatory and non inflammatory leisons by 59.2% and 40.8% respectively. Dapsone gel was found to be tolerable with minimal side effects. Conclusion: 5% Dapsone gel was well tolerated and efficacious in the treatment of mild to moderate acne vulgaris. Key words: acne vulgaris, 5% Dapsone gelReferences
Jawade SA, Singh A. Efficacy of Dapsone 5 % gel in treatment of acne vulgaris. International journal of research in dermatology. Oct 2016;2 (4). 77-83.
Alanazi , M.S , Hammad, S.M, Mohammad A.E. prevalence and psychological impact of acne vulgaris among female secondary school students in Arar city ,Saudi Arabia. Electronic physician , 2018; 10(8) .7224-7229, http://doi.org/10.19082/7224.
Babar O, Mobeen A. prevalence and psychological impact of acne vulgaris in female undergraduate medical students of Rawalpindi and Islamabad , Pakistan .cureus. sep 2019; 11(9).
Bhat YJ. Latief I, Hassan I. update on etiopathogenesis and treatment of acne . Indian Journal of Dermatology,venerologyand leprosy 2017; 83: 298-306.
Hazarika N. Acne vulgaris:new evidence in pathogenesis and future modalities of treatment . the journal of dermatological treatment , 2021; 32(3), 277-285.
Kircik, Leon H. Advances in the understanding of the pathogenesis of inflammatory acne. Journal of drugs in dermatology: SDD vol,15. Suppl 1 (2016): s7-10.
Conzalez –Mondragen, Edgar A et al. acne and diet : a review of pathogenic mechanisms. Boletin medico del hospital infantile de mexico. Vol 79,2 (2022) : 83-90.
Stotland M, Shalia Atan R, Kissling Robert F. Dapsone 5 % gel, a review of its efficacy and safety in the treatment og acne vulgaris, Am j clin dermatol 2009; 10(4) :221-227.
Kirick L. Harnessing. The anti inflammatory effects of topical dapsone for management of acne. J. Drugs Dermatol. 2010: 9(6): 667-71.
Kosmadaki M, Katisambas A. Topical treatments for acne. Clinics in dermatology. 2017 March 1 ; 35(2) :173-8.
Neritia Hazarika, M. Archana. The psychological impact of Acne vulgaris. Indian J Dermatol.sep- oct (2016) ;61(5): 515-520.
Kurokawa, Ichiro, Keisuke Nakase. Recent advances in understanding and managing acne. F 1000 Research vol 9. F 1000 Faculty Rev- 792, 29 Jul. 2020.
Ghaoui, Nohra et al. update on the use of dapsone in dermatology. International journal of dermatology vol.59, 7 (2020): 787-795.
Khalilzaedah, Mina et al. A comprehensive insight into the anti inflammatory properties of dapsone. Naunyn-Schmideeberg’s archives of pharmacology vol.395, 12 (2022): 1509-1523.
Xuesong Wang, Zhenzhen Wang et al. Efficacy and safety of dapsone gel for acne : a systematic review and meta analysis. Annals of Palliative medicine vol 11, No.2 (2022).
Nickles, M.A, Lake E. Topical dapsone in the treatment of acne: a systemic review. Int J. Dermatol, 61 : 2022. 1412-1421.
Tan J. Dapsone 5 % gel : a new option in topical therapy for acne . skin therapy letter vol.17, 18 (2012): 1-3.
Alexis, Andrew F.et al. The efficacy and safety of topical dapsone gel , 5% for the treatment of acne vulgaris in adult felames with skin colour. Journal of Drugs in Dermatology: JDD.15 (2): 2016 : 197-204.
Tanghetti, Emil.et al. clinical evidence for the role of topical anti inflammatory agent in comedonal acne, findings from a randomized study of dapsone gel 5 % in combination with tazoretene cream 0.1% in patients with acne vulgaris. Journal of drugs in dermatology: JDD .10(7) (2011): 783-792.
Lynde CW. Andriessen A. Cohort study on the treatment with dapsone 5 % gel of mild to moderate inflammatory acne of the face in women. Skin med . Jan-feb 2014; 12 (1): 15-21.
