Role of Omega-3 Supplements in Plaque-Type Psoriasis

Authors

  • Nopriyati Dermatology and Venereology Department, Sriwijaya University, Dr. Moh. General Hospital, Palembang, Indonesia.
  • Muhammad Athuf Thaha Dermatology and Venereology Department, Sriwijaya University, Dr. Moh. General Hospital, Palembang, Indonesia.
  • Sarah Diba Dermatology and Venereology Department, Sriwijaya University, Dr. Moh. General Hospital, Palembang, Indonesia.
  • Odelia Jovita Jusuf Fantoni Dermatology and Venereology Department, Sriwijaya University, Dr. Moh. General Hospital, Palembang, Indonesia
  • Grady Garfendo Dermatology and Venereology Department, Sriwijaya University, Dr. Moh. General Hospital, Palembang, Indonesia.

Abstract

Background: Psoriasis may severely affect patients’ quality of life, leading to depression and self-isolation. Effective treatments are limited by cumulative side-effects and tachyphylaxis. Previous studies have suggested a benefit of omega-3 in psoriasis therapy. Objectives: To evaluate the efficacy of omega-3 supplements in improving mild-moderate plaque psoriasis patients’ quality of life. Methods: This was an open, non-blinded interventional study comprised of thirty patients; 15 patients were given standard oral medication forming the control group while the remaining 15 were added omega-3 daily in three divided doses. Oral antihistamine agents were given accordingly. The assessments include baseline characteristics of participants, such as age, sex and severity of psoriasis by Dermatology Life Quality Index (DLQI) and Psoriasis Area Severity Index (PASI). Weekly visits were scheduled, with measurement of omega-3 level conducted in baseline and week 12. Results: There is no mean difference in baseline omega-3 levels between group A and group B (p>0,05) but at the end of study, omega-3 level of group B has improved significantly. PASI and DLQI score in group A and B compared to baseline were statistically significant (p<0,000), while group B had shown better improvement than group A. Conclusions: Improvements were observed in both groups with greater results suggested in the group additionally treated with omega-3 supplements.   Keywords: omega-3, psoriasis vulgaris, Psoriasis Area Severity Index, Dermatology Life Quality Index

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Published

2023-07-02

How to Cite

1.
Nopriyati, Thaha MA, Diba S, Fantoni OJJ, Garfendo G. Role of Omega-3 Supplements in Plaque-Type Psoriasis. J Pak Assoc Dermatol [Internet]. 2023Jul.2 [cited 2024Jun.17];33(2):543-6. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2169

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Original Articles