Assessment of CXCL10 and Vitamin D in patients with persistent Pityriasis rosea during Covid-19 pandemic


  • Hanan Farouk Aly Professor


Background: Pityriasis rosea (PR) is an exanthematous disorder accompanied by systemic reactivation of human herpesvirus- (HHV-) 6 and/or 7. Aim of the work: To explain the link between levels of vitamin D & CXCL10 in persistent PR during COVID-19.Methods: The study encompassed 25 patients (10 males and 15 females, age range: 10–40 years) with persistent PR more than 12 weeks & 25 control subjects (12 males & 13 females, age range: 11- 38 years) examined in the medical Excellence center, Dermatology Outpatient Clinic, National Research Center, Egypt between November 2020 & March 2021. Blood samples were collected from controls & persistent PR patients for more than 12 weeks after 15 days that frequently links to the topmost of clinical manifestations. Assessment of serum CXCL10 was done by ELISA kit. Vitamin D was determined using the chemi-luminescence technique .Results: A student unpaired T- test was done at P < 0.05 illustrating a significant increase in levels of CXCL10 while a significant decrease in levels of vitamin D in the sera of both male & female patients in comparison to control ones. Conclusion: Our study provided evidence that circulating CXCL10 is elevated in persistent PR patients as well as in Covid -19 where PR is one of clinical symptoms of corona virus. This highlights the immunological response in PR & contributes to a clear explanation of cutaneous defense mechanism. Vitamin D showed a significant reduction in persistent PR patients and has been shown to be safe & guard against acute respiratory infections as in COVID-19.




How to Cite

Farouk Aly H. Assessment of CXCL10 and Vitamin D in patients with persistent Pityriasis rosea during Covid-19 pandemic. J Pak Assoc Dermatol [Internet]. 2022Mar.29 [cited 2024Jun.17];32(1):117-22. Available from:



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