Assessment of CXCL10 and Vitamin D in patients with persistent Pityriasis rosea during Covid-19 pandemic
DOI:
https://doi.org/10.66344/jpad.32.1.2022.1853Abstract
Background: Pityriasis rosea (PR) is an exanthematous disorder accompanied by systemic reactivation of human herpesvirus- (HHV-) 6 and/or 7. Aim of the work: To explain the link between levels of vitamin D & CXCL10 in persistent PR during COVID-19.Methods: The study encompassed 25 patients (10 males and 15 females, age range: 10–40 years) with persistent PR more than 12 weeks & 25 control subjects (12 males & 13 females, age range: 11- 38 years) examined in the medical Excellence center, Dermatology Outpatient Clinic, National Research Center, Egypt between November 2020 & March 2021. Blood samples were collected from controls & persistent PR patients for more than 12 weeks after 15 days that frequently links to the topmost of clinical manifestations. Assessment of serum CXCL10 was done by ELISA kit. Vitamin D was determined using the chemi-luminescence technique .Results: A student unpaired T- test was done at P < 0.05 illustrating a significant increase in levels of CXCL10 while a significant decrease in levels of vitamin D in the sera of both male & female patients in comparison to control ones. Conclusion: Our study provided evidence that circulating CXCL10 is elevated in persistent PR patients as well as in Covid -19 where PR is one of clinical symptoms of corona virus. This highlights the immunological response in PR & contributes to a clear explanation of cutaneous defense mechanism. Vitamin D showed a significant reduction in persistent PR patients and has been shown to be safe & guard against acute respiratory infections as in COVID-19.
Downloads
Published
How to Cite
Issue
Section
License
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
