The effectivity of platelet rich plasma on melasma

a systematic review and meta-analysis

Authors

  • Ernawati Hidayat Departement of Dermatovenereology, Faculty of Medicine, Diponegoro University/ Dr. Kariadi General Hospital Medical Center, Jl. Dr. Sutomo No.16, 50244, Semarang, Indonesia.
  • Asih Budiastuti Departement of Dermatovenereology, Faculty of Medicine, Diponegoro University/ Dr. Kariadi General Hospital Medical Center, Jl. Dr. Sutomo No.16, 50244, Semarang, Indonesia.
  • Diah Adriani Malik Departement of Dermatovenereology, Faculty of Medicine, Diponegoro University/ Dr. Kariadi General Hospital Medical Center, Jl. Dr. Sutomo No.16, 50244, Semarang, Indonesia.
  • Retno Indar Widayati Departement of Dermatovenereology, Faculty of Medicine, Diponegoro University/ Dr. Kariadi General Hospital Medical Center, Jl. Dr. Sutomo No.16, 50244, Semarang, Indonesia.
  • Puguh Riyanto Departement of Dermatovenereology, Faculty of Medicine, Diponegoro University/ Dr. Kariadi General Hospital Medical Center, Jl. Dr. Sutomo No.16, 50244, Semarang, Indonesia.
  • Muslimin Departement of Dermatovenereology, Faculty of Medicine, Diponegoro University/ Dr. Kariadi General Hospital Medical Center, Jl. Dr. Sutomo No.16, 50244, Semarang, Indonesia.
  • Hardian Departement of Physiology, Faculty of Medicine, Diponegoro University, Jl. Prof. Soedarto, Tembalang, 50275, Semarang, Indonesia.

Abstract

Background: Melasma is an acquired hyperpigmentation in the form light brown to dark brown macules on areas exposed to Ultraviolet (UV). Melasma accounts for 50% of aesthetic cases in Asia. Therapy of melasma depends on the type of melasma, the effectiveness of previous therapies, and the patient's expectations. Difficult in the management of melasma are frequent recalcitrant, tendency of recurrence, risk of side effects, long treatment and patient compliance. The latest therapy that is being used is Platelet rich plasma (PRP) containing TGF-β1 which significantly suppresses melanin synthesis, thereby lowering the mMASI score of melasma patients. Methods: Searching the electronic database Medline Pubmed, Scopus, EBSCOhost, ProQuest, Cochrane library, ClinicalTrials.gov, found 5 articles included in the qualitative (n = 154 subjects) and 4 articles (n = 103 subjects) included in the meta-analysis. . Results: The mean difference in mMASI scores before treatment in the PRP injection treatment group and the control group was negative. This value indicates a decrease in the mMASI score after PRP injection. The control group also showed the same thing. The greatest decrease in mMASI scores in the study by Gamea, 2020 with PRP injection and topical tranexamic acid treatment was -8.5±2.76, the smallest in the study by Sirithanabadeekul, 2019 in the control group receiving normal saline injection, which was -1.42 ±0.93. The results of the heterogeneity test showed the value of Q value = 24,564, df = 3; p<0.001, I2= 87.787. The results of the I2 test with p < 0.001 showed that the data was homogeneous. The results of the meta-analysis showed that the value of the Q statistic was the value of z= -5.373 (p=<0.001). This shows that overall offering PRP can significantly reduce the mMASI score. Conclusions: The results of the systematic and meta-analysis carried out can be said that those who were given PRP intradermal injection therapy there was a decrease in mMASI scores that had occurred before treatment. The decrease in mMASI scores in the group given platelet rich plasma was lower than the control group given tranexamic acid injection in melasma patients.   Keywords: Platelet rich plasma, melasma, mMASI, tranexamid acid

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Published

2022-03-29

How to Cite

1.
Hidayat E, Budiastuti A, Malik DA, Widayati RI, Riyanto P, Muslimin, Hardian. The effectivity of platelet rich plasma on melasma: a systematic review and meta-analysis. J Pak Assoc Dermatol [Internet]. 2022Mar.29 [cited 2024May19];32(1):103-16. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1844

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