A study analysing the effect of wet wraps in patients of Atopic Dermatitis
DOI:
https://doi.org/10.66344/jpad.v31i4.1798Abstract
Objective We sought to evaluate the efficacy of wet wrap therapy treatment in patients with Atopic dermatitis.
Methods Total 30 patients, (25 males and 5 females) were enrolled in this study with severe dermatitis [SCORAD] score ≥50) were enrolled in this study. For disease severity SCORAD was used, for quality of life dermatology life quality index (DLQI) scores, visual analog scale (VAS) for pruritus and investigator’s global assessment (IGA) was used. For evaluation of water content in the corneum, the capacitance was measured by Corneometer (Courage and Khazaka, Cologne, Germany), and TEWL was measured by Tewameter TM210 (Courage and Khazaka). The lipid amount of skin surface was assessed by Sebumeter (Courage and Khazaka). The patients underwent WWT (daily dose: 15 g Mometasone furoate cream+100g Vaseline ointment) twice daily for 2 h/session for 7 days.
Results There was significant improvement in lesions, quality of life and itching. SCORAD was clearly decreased, epidermal water content was increased, and transepidermal water loss was decreased after wet-wrap dressing.
Conclusion Wet wrap therapy (WWT) can relieve pruritus, reduce skin lesions, and improve quality of life.
References
1. Huiling He MD, Haur Yueh Lee, Seng Bin Ang. Pilot study of a customized nanotextile wet garment treatment on moderate and severe atopic dermatitis: A randomized clinical trial. Pediatr Dermatol.2020;37:52-7.
2. Hainan Yue, Yoshie Umehara, Juan Valentin T P, et al. Exogenous factors in the pathogenesis of atopic dermatitis: Irritants and cutaneous infections. Clin Exp Allergy.2021;51(3):382-92.
3. Hanifin JM, Rajka G. Diagnostic features of atopic eczema. Acta Derm Venereol.1980; 92:44–7.
4. Egawa G, Kabashima K. Multifactorial skin barrier deficiency and atopic dermatitis: essential topics to prevent the atopic march. J Allergy Clin Immunol.2016;138(2):350–8.
5. Sandeep Kapur, Wade Watson, Stuart Carr. Atopic Dermatitis. Allergy Asthma Clin Immunol.2018;14(Suppl 2):52.
https://doi.org/10.1186/s13223-018-0281-6
6. Catherine Drislane, Alan D Irvine. The role of filaggrin in atopic dermatitis and allergic disease. Ann Allergy Asthma Immunol. 2020;124(1):36-43.
7. Nicol NH, Boguniewicz M, Strand M, Klinnert MD. Wet wrap therapy in children with moderate to severe atopic dermatitis in a multidisciplinary treatment program. J Allergy Clin Immunol Pract.2014;2(4):400‐6.
8. Lee JH, Lee SJ, Kim D, Bang D. The effect of wet‐wrap dressing on epidermal barrier in patients with atopic dermatitis. J Eur Acad Dermatol Venereol.2007;21(10):1360‐8.
9. Ong PY, Ferdman RM, Dunaway T, Church JA, Inderlied CB. Down‐ regulation of atopic dermatitis‐associated serum chemokines by wet‐wrap treatment: a pilot study. Ann Allergy Asthma Immunol.2008;100(3):286‐7.
10. Ong PY, Ferdman RM, Dunaway T, Church JA, Inderlied CB. Down‐ regulation of atopic dermatitis‐associated serum chemokines by wet‐wrap treatment: a pilot study. Ann Allergy Asthma Immunol.2008; 100(3):286‐7.
11. Andersen R, Thyssen J, Maibach H. The role of wet wrap therapy in skin disorders – a literature review. Acta Derm Venereol. 2015;95(8):933‐9.
12. Sherief R. Janmohamed, Arnold P. Oranje, Arjan C. Devillers et al. The proactive wet-wrap method with diluted corticosteroids versus emollients in children with atopic dermatitis: A prospective, randomized, double-blind, placebo-controlled trial. J Am Acad Dermatol.2014;70(6):1076-82
13. Cadmus SD; Sebastian KR; Warren D et al. Efficacy and patient opinion of wet – wrap dressing using 0.1% triamcinolone acetonide ointment vs. cream in the treatment of pediatric atopic dermatitis: A randomized split body control study. Pediatr Dermatol.2019;36(4):437-41.
14. Nicol NH, Boguniewicz M, Strand M, et al. Wet wrap therapy in children with moderate to severe atopic dermatitis in a multidisciplinary treatment program. J Allergy Clin Immunol Pract.2014;2:400- 6.
15. Bingham LG, Noble JW, Davis MD. Wet dressings used with topical corticosteroids for pruritic dermatoses: a retrospective study. J Am Acad Dermatol.2009;60(5):792.
16. Albarrán Planelles C, Jiménez Gallo D, Linares Barrios M. Our experience with wet-wrap treatment. Actas Dermosifiliogr.2014;105(3):e18.
17. Wollenberg A, Oranje A, Deleuran M, et al. ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients. J Eur Acad Dermatol Venereol. 2016;30(5):729–47.
18. Devillers AC, Oranje AP. Wet-wrap treatment in children with atopic dermatitis: a practical guideline. Pediatr Dermatol. 2012;29(1):24–7.
19. Janmohamed SR, Oranje AP, Devillers AC, et al. The proactive wetwrap method with diluted corticosteroids versus emollients in children with atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled trial. J Am Acad Dermatol.2014;70(6):1076–82.
20. Oranje AP, Devillers AC, Kunz B, et al. Treatment of patients with atopic dermatitis using wet-wrap dressings with diluted steroids and/or emollients. An expert panel’s opinion and review of the literature. An expert panel’s opinion and review of the literature. J Eur Acad Dermatol Venereol. 2006;20(10):1277–86.
21. Gonzã LG, Ceballos-RodrãGuez RM, Gonzã lez-LÃ3pez JJ, et al. Efficacy and safety of wet wrap therapy for patients with atopic dermatitis: a systematic review and meta-analysis. Br J Dermatol.2017;177(3):688.
22. Werner Y. The water content of the stratum corneum in patients with atopic dermatitis. Acta Derm Venereol.1986;66:281–4.
23. Pilgram G, Vissers D, van der Meulen H et al. Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis. J Invest Dermatol. 2001;117:710–7.
24. Foelster-Holst R, Nagel F, Zoellner P, Spaeth D. Efficacy of crisis intervention treatment with topical corticosteroid prednicarbat with and without partial wet-wrap dressing in atopic dermatitis. Dermatology.2006;212:66–9.
25. He.Huiling, Koh, Mark J. Aan, et al. Pilot study of a customized nanotextile wet garment treatment on moderate and severe atopic dermatitis: A randomized clinical trial. Pediatr Dermatol.2020;37(1):52–7.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Shafia Nisar Kakroo, Mirza Aumir Beg, Basit Kakroo

This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.






