A study analysing the effect of wet wraps in patients of Atopic Dermatitis

Abstract

Background: Atopic dermatitis (AD) is a common dermatosis. The important part of management is to repair and maintain skin barrier and hydration, as well as to reduce inflammation. Wet wrap therapy (WWT) has shown a satisfactory effectiveness, but clinical evidence supporting the use of WWT on severe adult AD is still insufficient.Methods: Total 30 patients, (25 males and 5 females) were enrolled in this study with severe dermatitis [SCORAD] score ≥ 50) were enrolled in this study. For disease severity SCORAD was used, for quality of life dermatology life quality index (DLQI) scores, visual analog scale (VAS) for pruritus and investigator’s global assessment (IGA) was used. For evaluation of water content in the corneum, the capacitance was measured by Corneometer (Courage and Khazaka, Cologne, Germany), and TEWL was measured by Tewameter TM210 (Courage and Khazaka). The lipid amount of skin surface was assessed by Sebumeter (Courage and Khazaka). The patients underwent WWT (daily dose: 15 g Mometasone furoate cream+100g Vaseline ointment) twice daily for 2 h/session for 7 days.Results: There was significant improvement in lesions, quality of life and itching. SCORAD was clearly decreased, epidermal water content was increased, and transepidermal water loss was decreased after wet-wrap dressing. Conclusion: Wet wrap therapy (WWT) can relieve pruritus, reduce skin lesions, and improve quality of life