Serum prolactin concentration in psoriatic patients and its relationship with disease activity

Abstract

Background: Psoriasis is a T-cell mediated hyper proliferative cutaneous disease of multifactorial etiology. Recent lines of experiments suggest that prolactin as a neuro-hormone may play a role in the activity of psoriasis. Objectives: To identify the correlations of serum prolactin concentration with disease activity of psoriatic patients.Methods: A cross sectional study was conducted in the department of Dermatology & Venereology at Bangabandhu Sheikh Mujib Medical University from September 2016 to December 2017. Fifty individuals diagnosed as psoriasis, according to inclusion and exclusion criteria, was included and consecutive type of sampling technique was applied to collect the sample. Psoriasis Area and Severity Index (PASI) was calculated in each patient for measurement of disease activity.Result: The mean age of the psoriatic patients was 39.64 ± 15.51 years and mean BMI of the patients was 22.43 ± 1.16 kg/m2 within the range of 19.9 – 25.39. Study showed that serum prolactin gradually increased according to the increment of PASI score and serum prolactin had significant positive correlation with PASI score (r=0.821; p = <0.001) and patients with joint involvement had significantly higher serum prolactin level.Conclusion: Present study revealed a positive correlation between disease activity of psoriasis with patient’s serum prolactin concentration. So, serum prolactin can be considered as marker of disease activity.