Serum prolactin concentration in psoriatic patients and its relationship with disease activity
DOI:
https://doi.org/10.66344/jpad.v32i1.1797Abstract
Background Psoriasis is a dermatological disease of T lymphocyte origin and has multiple etiological backgrounds. Recent lines of researches suggest that prolactin as a neurohormone may have a role in the disease activity of psoriasis.
Objective To identify the correlations of serum prolactin concentration with disease activity of psoriatic patients.
Methods In the department of Dermatology & Venereology at Bangabandhu Sheikh Mujib Medical University, this cross sectional study was conducted. Time period was from September 2016 to December 2017. Fifty individuals diagnosed as psoriasis were included. Subjects were enrolled according to specific criteria. Consecutive sampling method was applied to choose the samples. For measurement of disease activity of each subject, Psoriasis Area and Severity Index (PASI) was implemented.
Results In this study, 39.64±15.51 years was mean age of the subjects and mean BMI was 22.43±1.16 kg/m2 within the range of 19.9–25.39. Study showed that serum prolactin gradually increased according to the increment of PASI score and serum prolactin had positive correlation with PASI score (r=0.821; p≤0.001) which was accepted as significant statistically. Patients with joint involvement had significantly higher serum prolactin level.
Conclusion A positive correlation between psoriatic disease activity with concentration of patient’s serum prolactin was observed in this study. So, serum prolactin may be esteemed as a marker of psoriatic disease activity.
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Copyright (c) 2022 Rehnuma Nasim, Abida Sultana, Lubna Khondker, Mohammad Omar Faruque, Farhana Wahab, Hasan Mahmud, Khyrun Nahar Shaila
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