Cytokeratin 17, Cytokeratin 19 and BerEP4 expression in basal cell carcinoma and adjacent epithelial structures of the skin

Authors

  • Vladimír Bartoš Martin´s Biopsy Center, Ltd., Martin, Slovakia

DOI:

https://doi.org/10.66344/jpad.v31i2.1637

Abstract

Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor commonly affecting perineum of female, but also inflicting analogue area of male in lower incidence. We describe a 22-year-old man with a pedunculated, soft tumor, sized 10x5x7 cm in largest part, on his gluteal sinistra area.  The tumor was completely excised, and histology examination showed squamous epithelia, spindle- and stellate-shaped cells within myxoid stoma without mitotic figures, fibrosis in some area, and thick-walled blood vessels. No recurrence was observed until 1-year follow-up after surgery. 

References

1. Sutton BJ, Laudadio J. Aggressive angiomyxoma. Arch Pathol Lab Med.2012;136(2):217–21.

2. Chan IM, Hon E, Ngai SW, Ng TY, Wong LC. Aggressive angiomyxoma in females: Is radical resection the only option? Acta Obstet Gynecol Scand.2000;79(3):216-20;

3. Iezzoni JC, Fechner RE, Wong LS, Rosai J. Aggressive angiomyxoma in males: A report of four cases. Am J Clin Pathol.1995; 104(4):391-6.

4. McCluggage WG, Patterson A, Maxwell P. Aggressive angiomyxoma of pelvic parts exhibits oestrogen and progesterone receptor positivity. J Clin Pathol.2000;53(8):603-5.

5. Idrees MT, Hoch BL, Wang BY, Unger PD. Aggressive angiomyxoma of male genital region. Report of 4 cases with immunohistochemical evaluation including hormone receptor status. Ann Diagn Pathol. 2006;10(4):197-204.

6. Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol.1983;7(5):463-75.

7. Martinez MA, Ballestín C, Carabias E, Lois CG. Aggressive angiomyxoma: An ultrastructural study of four cases. Ultrastruct Pathol.2003;27(4):227-33.

8. Van Roggen JFG, Van Unnik JAM, Briaire-De Bruijn IH, Hogendoorn PCW. Aggressive angiomyxoma: A clinicopathological and immunohistochemical study of 11 cases with long-term follow-up. Virchows Arch. 2005.

9. Ducarme G, Valentin M, Davitian C, Felce-Dachez M, Luton D. Angiomyofibroblastoma: A rare vulvar tumor. Arch Gynecol Obstet.2010; 281(1):161-2.

10. Fletcher CDM, Tsang WYW, Fisher C, Lee KC, Chan JKC. Angiomyofibroblastoma of the vulva: A benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol.1992;16(4):373-82.

11. Allen PW, Dymock RB, MacCormac LB. Superficial angiomyxomas with and without epithelial components. Report of 30 tumors in 28 patients. Am J Surg Pathol.1988;12(7):519-30

12. Han-Geurts IJM, van Geel AN, van Doorn L, M. den Bakker, Eggermont AMM, Verhoef C. Aggressive angiomyxoma: multimodality treatments can avoid mutilating surgery. Eur J Surg Oncol.2006;32(10):1217-21.

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Published

06.08.2021

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Section

Original Articles

How to Cite

1.
Cytokeratin 17, Cytokeratin 19 and BerEP4 expression in basal cell carcinoma and adjacent epithelial structures of the skin. J Pak Assoc Dermatol [Internet]. 2021 Aug. 6 [cited 2026 Sep. 16];31(2):153-7. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1637